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. 2024 Mar 19:15:1359182.
doi: 10.3389/fendo.2024.1359182. eCollection 2024.

Is the leptin/BMI ratio a reliable biomarker for endometriosis?

Aleksandra Zyguła  1 , Anna Sankiewicz  2 , Agata Sakowicz  3 , Ewa Dobrzyńska  4 , Agnieszka Dakowicz  5 , Grzegorz Mańka  6 , Mariusz Kiecka  6 , Robert Spaczynski  7   8 , Piotr Piekarski  9 , Beata Banaszewska  10 , Artur Jakimiuk  11   12 , Tadeusz Issat  13 , Wojciech Rokita  14   15 , Jakub Młodawski  14   15 , Maria Szubert  16   17 , Piotr Sieroszewski  16   18 , Grzegorz Raba  19   20 , Kamil Szczupak  19   20 , Tomasz Kluza  21 , Marek Kluza  21 , Piotr Pierzyński  1 , Cezary Wojtyla  1   22 , Michal Lipa  23 , Damian Warzecha  1   24   25 , Miroslaw Wielgos  23   26   27 , Krzysztof Cendrowski  4 , Ewa Gorodkiewicz  2 , Piotr Laudanski  1   4   22
Affiliations

Is the leptin/BMI ratio a reliable biomarker for endometriosis?

Aleksandra Zyguła et al. Front Endocrinol (Lausanne). .

Abstract

Background: The aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis.

Materials & methods: Leptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis).

Results: Leptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785).

Conclusion: The results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.

Keywords: endometriosis; infertility; leptin; peritoneal fluid; plasma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The means of leptin/BMI ratio in plasma depending of endometriosis and primary infertility.
Figure 2
Figure 2
The means of leptin/BMI ratio in peritoneal fluid depending of endometriosis and primary infertility.
Figure 3
Figure 3
The means of leptin/BMI ratio in plasma depending of endometriosis and infertility.
Figure 4
Figure 4
The means of leptin/BMI ratio in PE depending of endometriosis and infertility.
Figure 5
Figure 5
Correlations between plasma and peritoneal fluid Leptin/BMI ratio in endometriosis group (N=38).
Figure 6
Figure 6
Correlations between plasma and peritoneal fluid Leptin/BMI ratio in control group (N=27).
Figure 7
Figure 7
Correlations between rAFS stage of disease & Leptin/BMI ratio in plasma (rs=0.28; p=0.0871; N=39).
Figure 8
Figure 8
rAFS stage of disease & Leptin/BMI ratio in PF (rs=0.05; p=0.7570; N=37).
See this image and copyright information in PMC

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