Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Oct;37(5):1099-1111.
doi: 10.1007/s10534-024-00594-1. Epub 2024 Apr 3.

Effects of arsenic exposure on blood trace element levels in rats and sex differences

Xiaoqian Ran  1   2 , Xi Yan  1   2 , Hongbin Zhuang  1 , Zhiyuan Liang  1 , Guanwei Ma  1   2 , Xiaolu Chen  1   2 , Yuhan Huang  1 , Xukun Liu  1 , Peng Luo  2 , Ting Hu  2 , Jun Zhang  1   2 , Liming Shen  3   4
Affiliations

Effects of arsenic exposure on blood trace element levels in rats and sex differences

Xiaoqian Ran et al. Biometals. 2024 Oct.

Abstract

Arsenic (As) is a widespread environmental metalloid and human carcinogen, and its exposure is associated with a wide range of toxic effects, leading to serious health hazards. As poisoning is a complex systemic multi-organ and multi-system damage disease. In this study, a rat model of As poisoning was established to investigate the levels of trace elements in the blood of rats and sex differences in the effect of As on every trace elements in rat blood. Twenty 6-week-old SD (Sprague Dawley) rats were randomly divided into the control group and the As-exposed group. After 3 months, the contents of 19 elements including As in the blood were detected in these two groups by inductively coupled plasma mass spectrometry (ICP-MS). As levels in the blood of As-exposed rats were significantly higher than those in the control group, with increased levels of Rb, Sr, Cs and Ce, and decreased levels of Pd. As showed a significant positive correlation with Rb. There were significant sex differences in blood Se, Pd, Eu, Dy, Ho, and Au levels in the As-exposed group. The results showed that As exposure can lead to an increase of As content in blood and an imbalance of some elements. There were sex differences in the concentration and the correlation between elements of some elements. Elemental imbalances may affect the toxic effects of As and play a synergistic or antagonistic role in As toxicity.

Keywords: As exposure; Blood; Element imbalance; Sex differences.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. Ali SA, Peet M, Ward NI (1985) Blood levels of vanadium, caesium, and other elements in depressive patients. J Affect Disord 9:187–191. https://doi.org/10.1016/0165-0327(85)90100-4 - DOI - PubMed
    1. Andrade V, Mateus ML, Santos D et al (2014) Arsenic and manganese alter lead deposition in the rat. Biol Trace Elem Res 158:384–391. https://doi.org/10.1007/s12011-014-9954-2 - DOI - PubMed
    1. Bhardwaj P, Dhawan DK (2019) Zinc treatment modulates hematological and morphological changes in rat erythrocytes following arsenic exposure. Toxicol Ind Health 35:593–603. https://doi.org/10.1177/0748233719878563 - DOI - PubMed
    1. Biagini RE, Bernstein IL, Gallagher JS et al (1985) The diversity of reaginic immune responses to platinum and palladium metallic salts. J Allergy Clin Immunol 76:794–802. https://doi.org/10.1016/0091-6749(85)90750-x - DOI - PubMed
    1. Cabrera WE, Schrooten I, De Broe ME, D’Haese PC (1999) Strontium and bone. J Bone Miner Res 14:661–668. https://doi.org/10.1359/jbmr.1999.14.5.661 - DOI - PubMed

LinkOut - more resources