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. 2024 Jul;58(4):696-703.
doi: 10.1007/s43441-024-00638-1. Epub 2024 Apr 3.

Benchmarking Site Activation and Patient Enrollment

Mary Jo Lamberti  1 , Abigail Dirks  2 , Nicholas Kikuchi  3 , Neha Patel Cervantes  4 , Kenneth Getz  2
Affiliations

Benchmarking Site Activation and Patient Enrollment

Mary Jo Lamberti et al. Ther Innov Regul Sci. 2024 Jul.

Abstract

Clinical trial conduct poses numerous challenges, many pertaining to patient recruitment. The primary objectives of this study were to update benchmarks on site activation and patient enrollment gathered in previous Tufts CSDD studies and examine current usage of recruitment and retention tactics. The data collection focused on site activation and patient enrollment metrics used for studies. Analyses were conducted comparing results from 2012, 2019 and 2023. The results indicate that actual enrollments exceeded planned enrollments for a majority of studies and timelines were shorter than expected. In addition, differences were found for enrollment achievement by global region and site type. Further investigation into studies conducted during a later time frame and post-pandemic could be compared with current benchmarks to examine differences.

Keywords: Patient enrollment; Recruitment and retention tactics; Site activation.

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References

    1. Lamberti MJ, Mathias A, Myles J, et al. Evaluating the impact of patient recruitment and retention practices. Ther Innov Regul Sci. 2012;46(5):573–80. https://doi.org/10.1177/0092861512453040 . - DOI
    1. Lamberti MJ, Smith Z, Henry R, et al. Benchmarking patient recruitment and retention practices. Ther Innov Regul Sci. 2021;55:19–32. https://doi.org/10.1007/s43441-020-00186-4 . - DOI - PubMed
    1. Kaitin K. New global recruitment performance benchmarks yield mixed results. Tufts CSDD Impact Rep. 2020; 22(1).
    1. Fogel DB. Factors associated with clinical trials that fail and opportunities for improving the likelihood of success: a review. Contemp Clin Trials Commun. 2018;11:56–164. https://doi.org/10.1016/j.conctc.2018.08.001 . - DOI
    1. Hurtado-Chong A, Joeris A, Hess D, et al. Improving site selection in clinical studies: a standardised, objective multi-step method and first experience results. BMJ Open. 2017;7:e104796. https://doi.org/10.1136/bmjopen-2016-014796 . - DOI

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