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. 2024 Jun;17(2):553-560.
doi: 10.1007/s12194-024-00798-7. Epub 2024 Apr 3.

Monte carlo simulation study on the dose and dose-averaged linear energy transfer distributions in carbon ion radiotherapy

Akihisa Ishikawa  1   2   3 , Yusuke Koba  4 , Takuya Furuta  5 , Weishan Chang  6 , Shunsuke Yonai  4 , Shinnosuke Matsumoto  6 , Shintaro Hashimoto  5 , Yuta Hirai  6 , Tatsuhiko Sato  5
Affiliations

Monte carlo simulation study on the dose and dose-averaged linear energy transfer distributions in carbon ion radiotherapy

Akihisa Ishikawa et al. Radiol Phys Technol. 2024 Jun.

Abstract

Dose-averaged linear energy transfer (LETd) is conventionally evaluated from the relative biological effectiveness (RBE)-LETd fitted function used in the treatment planning system. In this study, we calculated the physical doses and their linear energy transfer (LET) distributions for patterns of typical CIRT beams using Monte Carlo (MC) simulation. The LETd was then deduced from the MC simulation and compared with that obtained from the conventional method. The two types of LETd agreed well with each other, except around the distal end of the spread-out Bragg peak. Furthermore, an MC simulation was conducted with the material composition of water and realistic materials. The profiles of physical dose and LETd were in good agreement for both techniques. These results indicate that the previous studies to analyze the minimum LETd in CIRT cases are valid for practical situations, and the material composition conversion to water little affects the dose distribution in the irradiation field.

Keywords: Carbon ion radiotherapy; Monte Carlo simulation; PHITS; RT-PHITS for CIRT; Retrospective study.

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