doi: 10.1158/2159-8290.CD-23-1500.
The Virtual Child
Richard J Gilbertson
1
2
, Sam Behjati
3
4
5
, Anna-Lisa Böttcher
6
7
, Marianne E Bronner
8
, Matthew Burridge
9
, Henrick Clausing
10
, Harry Clifford
11
, Tracey Danaher
12
, Laura K Donovan
13
, Jarno Drost
14
15
, Alexander M M Eggermont
14
, Chris Emerson
11
, Mona G Flores
16
, Petra Hamerlik
17
, Nada Jabado
18
, Andrew Jones
9
, Henrick Kaessmann
19
, Claudia L Kleinman
20
21
, Marcel Kool
6
7
14
, Lena M Kutscher
6
22
, Gavin Lindberg
23
, Emily Linnane
1
2
, John C Marioni
1
3
24
, John M Maris
25
26
, Michelle Monje
27
, Alexandra Macaskill
28
, Steven Niederer
29
, Paul A Northcott
30
, Elizabeth Peeters
31
, Willemijn Plieger-van Solkema
32
, Liane Preußner
33
, Anne C Rios
14
, Karsten Rippe
34
, Peter Sandford
9
, Nikolaos G Sgourakis
26
35
, Adam Shlien
36
, Pete Smith
37
, Karin Straathof
38
39
, Patrick J Sullivan
40
, Mario L Suvà
41
42
, Michael D Taylor
43
, Emma Thompson
44
, Roser Vento-Tormo
3
, Brandon J Wainwright
45
, Robert J Wechsler-Reya
46
, Frank Westermann
6
47
, Shannon Winslade
44
, Bissan Al-Lazikani
48
, Stefan M Pfister
6
7
Affiliations
Affiliations
- 1 CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
- 2 Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
- 3 Wellcome Sanger Institute, Hinxton, United Kingdom.
- 4 Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
- 5 Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
- 6 Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
- 7 Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
- 8 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
- 9 Amazon Web Services, London, United Kingdom.
- 10 SELECT SouthWest, Germany.
- 11 NVIDIA, Cambridge, United Kingdom.
- 12 Children's Cancer Foundation, Australia.
- 13 University College London Great Ormond Street Institute of Child Health, United Kingdom.
- 14 Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
- 15 Oncode Institute, Utrecht, the Netherlands.
- 16 NVIDIA, Santa Clara, California.
- 17 University of Manchester, Manchester, United Kingdom.
- 18 Department of Paediatrics, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
- 19 Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
- 20 Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada.
- 21 Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
- 22 Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 23 The EVAN Foundation, Maryland.
- 24 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
- 25 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
- 26 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
- 27 Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
- 28 AstraZeneca, Oncology R&D, Cambridge, United Kingdom.
- 29 Turing Research and Innovation Cluster in Digital Twins (TRIC: DT), The Alan Turing Institute, London, United Kingdom.
- 30 Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee.
- 31 b.r.a.i.n.child, SickKids Hospital, Toronto, Ontario, Canada.
- 32 Dutch Childhood Cancer Organization (VKKN), the Netherlands.
- 33 BioNTech SE, Mainz, Germany.
- 34 German Cancer Research Center (DKFZ) Heidelberg, Division of Chromatin Networks, Heidelberg, Germany.
- 35 Department of Pathology and Lab Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
- 36 Genetics and Genomics Program, The Hospital for Sick Children, Toronto, Canada.
- 37 Hula Therapeutics, Philadelphia, Pennsylvania.
- 38 University College London Cancer Institute, London, United Kingdom.
- 39 Great Ormond Street Hospital for Children, London, United Kingdom.
- 40 Team Finn Foundation, Vancouver, British Columbia, Canada.
- 41 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
- 42 Broad Institute of MIT and Harvard, Boston, Massachusetts.
- 43 Texas Children's Cancer Center, Hematology-Oncology Section and Department of Pediatrics - Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, Texas.
- 44 Brain Tumour Charity, Fleet, United Kingdom.
- 45 The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.
- 46 Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
- 47 Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 48 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
- PMID: 38571421
- DOI: 10.1158/2159-8290.CD-23-1500
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The Virtual Child
Richard J Gilbertson et al.
Cancer Discov.
.
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doi: 10.1158/2159-8290.CD-23-1500.
Authors
Richard J Gilbertson
1
2
, Sam Behjati
3
4
5
, Anna-Lisa Böttcher
6
7
, Marianne E Bronner
8
, Matthew Burridge
9
, Henrick Clausing
10
, Harry Clifford
11
, Tracey Danaher
12
, Laura K Donovan
13
, Jarno Drost
14
15
, Alexander M M Eggermont
14
, Chris Emerson
11
, Mona G Flores
16
, Petra Hamerlik
17
, Nada Jabado
18
, Andrew Jones
9
, Henrick Kaessmann
19
, Claudia L Kleinman
20
21
, Marcel Kool
6
7
14
, Lena M Kutscher
6
22
, Gavin Lindberg
23
, Emily Linnane
1
2
, John C Marioni
1
3
24
, John M Maris
25
26
, Michelle Monje
27
, Alexandra Macaskill
28
, Steven Niederer
29
, Paul A Northcott
30
, Elizabeth Peeters
31
, Willemijn Plieger-van Solkema
32
, Liane Preußner
33
, Anne C Rios
14
, Karsten Rippe
34
, Peter Sandford
9
, Nikolaos G Sgourakis
26
35
, Adam Shlien
36
, Pete Smith
37
, Karin Straathof
38
39
, Patrick J Sullivan
40
, Mario L Suvà
41
42
, Michael D Taylor
43
, Emma Thompson
44
, Roser Vento-Tormo
3
, Brandon J Wainwright
45
, Robert J Wechsler-Reya
46
, Frank Westermann
6
47
, Shannon Winslade
44
, Bissan Al-Lazikani
48
, Stefan M Pfister
6
7
Affiliations
- 1 CRUK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
- 2 Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
- 3 Wellcome Sanger Institute, Hinxton, United Kingdom.
- 4 Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
- 5 Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom.
- 6 Hopp Children's Cancer Center (KiTZ), Heidelberg, Germany.
- 7 Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.
- 8 Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California.
- 9 Amazon Web Services, London, United Kingdom.
- 10 SELECT SouthWest, Germany.
- 11 NVIDIA, Cambridge, United Kingdom.
- 12 Children's Cancer Foundation, Australia.
- 13 University College London Great Ormond Street Institute of Child Health, United Kingdom.
- 14 Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
- 15 Oncode Institute, Utrecht, the Netherlands.
- 16 NVIDIA, Santa Clara, California.
- 17 University of Manchester, Manchester, United Kingdom.
- 18 Department of Paediatrics, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
- 19 Center for Molecular Biology of Heidelberg University (ZMBH), Heidelberg, Germany.
- 20 Lady Davis Research Institute, Jewish General Hospital, Montreal, Quebec, Canada.
- 21 Department of Human Genetics, McGill University, Montreal, Quebec, Canada.
- 22 Developmental Origins of Pediatric Cancer Junior Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 23 The EVAN Foundation, Maryland.
- 24 European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom.
- 25 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
- 26 Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.
- 27 Department of Neurology and Neurological Sciences, Stanford University, Stanford, California.
- 28 AstraZeneca, Oncology R&D, Cambridge, United Kingdom.
- 29 Turing Research and Innovation Cluster in Digital Twins (TRIC: DT), The Alan Turing Institute, London, United Kingdom.
- 30 Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, Tennessee.
- 31 b.r.a.i.n.child, SickKids Hospital, Toronto, Ontario, Canada.
- 32 Dutch Childhood Cancer Organization (VKKN), the Netherlands.
- 33 BioNTech SE, Mainz, Germany.
- 34 German Cancer Research Center (DKFZ) Heidelberg, Division of Chromatin Networks, Heidelberg, Germany.
- 35 Department of Pathology and Lab Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
- 36 Genetics and Genomics Program, The Hospital for Sick Children, Toronto, Canada.
- 37 Hula Therapeutics, Philadelphia, Pennsylvania.
- 38 University College London Cancer Institute, London, United Kingdom.
- 39 Great Ormond Street Hospital for Children, London, United Kingdom.
- 40 Team Finn Foundation, Vancouver, British Columbia, Canada.
- 41 Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
- 42 Broad Institute of MIT and Harvard, Boston, Massachusetts.
- 43 Texas Children's Cancer Center, Hematology-Oncology Section and Department of Pediatrics - Hematology/Oncology and Neurosurgery, Baylor College of Medicine, Houston, Texas.
- 44 Brain Tumour Charity, Fleet, United Kingdom.
- 45 The University of Queensland Frazer Institute, Translational Research Institute, Woolloongabba, Queensland, Australia.
- 46 Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York.
- 47 Division of Neuroblastoma Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 48 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas.
- PMID: 38571421
- DOI: 10.1158/2159-8290.CD-23-1500
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Abstract
We are building the world's first Virtual Child-a computer model of normal and cancerous human development at the level of each individual cell. The Virtual Child will "develop cancer" that we will subject to unlimited virtual clinical trials that pinpoint, predict, and prioritize potential new treatments, bringing forward the day when no child dies of cancer, giving each one the opportunity to lead a full and healthy life.
©2024 American Association for Cancer Research.
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