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Review
. 2024 Mar 20:11:1288710.
doi: 10.3389/fcvm.2024.1288710. eCollection 2024.

Influence of acidic metabolic environment on differentiation of stem cell-derived cardiomyocytes

Mao Jiahao  1 , Zhou Fan  2 , Mu Junsheng  1
Affiliations
Review

Influence of acidic metabolic environment on differentiation of stem cell-derived cardiomyocytes

Mao Jiahao et al. Front Cardiovasc Med. .

Abstract

Stem cell-based myocardial regeneration is a frontier topic in the treatment of myocardial infarction. Manipulating the metabolic microenvironment of stem cells can influence their differentiation into cardiomyocytes, which have promising clinical applications. pH is an important indicator of the metabolic environment during cardiomyocyte development. And lactate, as one of the main acidic metabolites, is a major regulator of the acidic metabolic environment during early cardiomyocyte development. Here, we summarize the progress of research into the influence of pH value and lactate on cardiomyocyte survival and differentiation, as well as related mechanisms.

Keywords: acidic metabolic environment; cardiac differentiation; lactate; pH value; stem cells.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Influence of pH value and lactate on key technologies of in vitro culture of pluripotent stem cell-derived cardiomyocytes.
See this image and copyright information in PMC

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