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Review
. 2024 Mar 8:15:1348076.
doi: 10.3389/fphar.2024.1348076. eCollection 2024.

Natural products reverse cancer multidrug resistance

Jia-Yu Zou #  1 , Qi-Lei Chen #  2 , Xiao-Ci Luo #  1 , Davaadagva Damdinjav #  3 , Usama Ramadan Abdelmohsen  4   5 , Hong-Yan Li  6 , Tungalag Battulga  3 , Hu-Biao Chen  2 , Yu-Qing Wang  1   7 , Jian-Ye Zhang  1   8
Affiliations
Review

Natural products reverse cancer multidrug resistance

Jia-Yu Zou et al. Front Pharmacol. .

Abstract

Cancer stands as a prominent global cause of death. One of the key reasons why clinical tumor chemotherapy fails is multidrug resistance (MDR). In recent decades, accumulated studies have shown how Natural Product-Derived Compounds can reverse tumor MDR. Discovering novel potential modulators to reduce tumor MDR by Natural Product-Derived Compounds has become a popular research area across the globe. Numerous studies mainly focus on natural products including flavonoids, alkaloids, terpenoids, polyphenols and coumarins for their MDR modulatory activity. Natural products reverse MDR by regulating signaling pathways or the relevant expressed protein or gene. Here we perform a deep review of the previous achievements, recent advances in the development of natural products as a treatment for MDR. This review aims to provide some insights for the study of multidrug resistance of natural products.

Keywords: MDR; cancer; mechanism; multidrug resistance; natural product-derived compounds.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mechanisms involved in cancer drug resistance.
FIGURE 2
FIGURE 2
Chemical structures of Flavonoids having MDR modulatory activity.
FIGURE 3
FIGURE 3
Chemical structures of Alkaloids, Polyphenols, Terpenoids and Coumarins having MDR modulatory activity.
See this image and copyright information in PMC

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