Innovative approaches to neonatal jaundice diagnosis and management in low-resourced settings
- PMID: 38572885
- PMCID: PMC10913041
- DOI: 10.4102/safp.v66i1.5833
Innovative approaches to neonatal jaundice diagnosis and management in low-resourced settings
Abstract
Persistent challenges in addressing severe neonatal hyperbilirubinaemia in resource-constrained settings have led to ongoing and often unacceptable rates of morbidity, disability and mortality. These challenges stem from limitations such as inadequate, inefficient or financially inaccessible diagnostic and therapeutic options. However, over the past decade, noteworthy innovations have emerged to address some of these hurdles, and these innovations are increasingly poised for broader implementation. This review provides a concise summary of these novel, economically viable diagnostic solutions, encompassing point-of-care assays and smartphone applications, as well as treatment modalities, notably more effective phototherapy and filtered sunlight. These advancements hold promise and have the potential to meaningfully reduce the burden of neonatal hyperbilirubinaemia, signifying a promising shift in the landscape of neonatal healthcare.
Keywords: bilirubin; hyperbilirubinaemia; neonatal jaundice; phototherapy; resource-constrained.
Conflict of interest statement
The author declares that they have no financial or personal relationships that may have inappropriately influenced them in writing this article.
Figures
Similar articles
-
Fluid supplementation for neonatal unconjugated hyperbilirubinaemia.Cochrane Database Syst Rev. 2017 Aug 1;8(8):CD011891. doi: 10.1002/14651858.CD011891.pub2. Cochrane Database Syst Rev. 2017. PMID: 28762235 Free PMC article.
-
Transcutaneous bilirubinometry for detecting jaundice in term or late preterm neonates.Cochrane Database Syst Rev. 2024 May 28;5(5):CD011060. doi: 10.1002/14651858.CD011060.pub2. Cochrane Database Syst Rev. 2024. PMID: 38804265 Free PMC article.
-
Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates.Cochrane Database Syst Rev. 2011 Dec 7;2011(12):CD007969. doi: 10.1002/14651858.CD007969.pub2. Cochrane Database Syst Rev. 2011. PMID: 22161417 Free PMC article.
-
First in-human pilot study of wearable phototherapy for neonatal hyperbilirubinaemia.Eur J Pediatr. 2025 Jun 9;184(7):407. doi: 10.1007/s00431-025-06239-w. Eur J Pediatr. 2025. PMID: 40488806 Free PMC article.
-
Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia.Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD009017. doi: 10.1002/14651858.CD009017.pub2. Cochrane Database Syst Rev. 2012. PMID: 23235669 Free PMC article.
Cited by
-
Neonatal Jaundice Treatment Versus Recommendations: The Challenge of Treatment Without Rapid Diagnostic Capability.Int J Environ Res Public Health. 2025 Jun 28;22(7):1032. doi: 10.3390/ijerph22071032. Int J Environ Res Public Health. 2025. PMID: 40724099 Free PMC article.
-
Neonatal Hyperbilirubinemia: A Case of Complex Management Involving ABO Incompatibility, Sepsis, and Suspected G6PD Deficiency treated with Methyl Prednisolone.Niger Med J. 2024 Nov 6;65(5):800-806. doi: 10.60787/nmj-v65i3.498. eCollection 2024 Sep-Oct. Niger Med J. 2024. PMID: 39633702 Free PMC article.
References
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Miscellaneous