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Review
. 2024 May 1;46(4):211-215.
doi: 10.1097/MPH.0000000000002853. Epub 2024 Apr 4.

Very Long-term Survivorship in Pediatric DIPG: Case Report and Review of the Literature

Evan Dimentberg  1 , Marie-Pier Marceau  1 , Alexandre Lachance  1 , Samuel Bergeron-Gravel  2 , Stephan Saikali  3 , Louis Crevier  4 , Catherine Bourget  5 , Cynthia Hawkins  6 , Nada Jabado  7 , Panagiota Giannakouros  8 , Samuele Renzi  8 , Valérie Larouche  8
Affiliations
Review

Very Long-term Survivorship in Pediatric DIPG: Case Report and Review of the Literature

Evan Dimentberg et al. J Pediatr Hematol Oncol. .

Abstract

Diffuse intrinsic pontine gliomas are lethal tumors with a prognosis generally less than 1 year. Few cases of survivors of 5 years or more have been reported. This case report highlights the journey of a 9.5-year survivor who underwent 3 rounds of focal radiotherapy; she experienced 6 years of progression-free survival following the first round but ultimately succumbed to her disease. An autopsy revealed a favorable IDH1 mutation and the absence of H3K27M. This case reiterates the importance of extensive molecular analyses in diffuse intrinsic pontine gliomas and explores the potential benefit of re-irradiation in patients with positive responses and long periods of remission.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

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