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Review
. 2024 Jun;21(6):e202400402.
doi: 10.1002/cbdv.202400402. Epub 2024 May 9.

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Naoual El Menyiy  1 , Youssef Elouafy  2 , Rania Moubachir  3 , Rhizlan Abdnim  4 , Taoufiq Benali  5 , Douae Taha  6 , Asaad Khalid  7   8 , Ashraf N Abdalla  9 , Siddiqa M A Hamza  10 , Salma Elhadi Ibrahim  11 , Mohamed El-Shazly  12 , Gokhan Zengin  13 , Abdelhakim Bouyahya  14
Affiliations
Review

Chemistry, Biological Activities, and Pharmacological Properties of Gastrodin: Mechanism Insights

Naoual El Menyiy et al. Chem Biodivers. 2024 Jun.

Abstract

Gastrodin, a bioactive compound derived from the rhizome of the orchid Gastrodia elata, exhibits a diverse range of biological activities. With documented neuroprotective, anti-inflammatory, antioxidant, anti-apoptotic, and anti-tumor effects, gastrodin stands out as a multifaceted therapeutic agent. Notably, it has demonstrated efficacy in protecting against neuronal damage and enhancing cognitive function in animal models of Alzheimer's disease, Parkinson's disease, and cerebral ischemia. Additionally, gastrodin showcases immunomodulatory effects by mitigating inflammation and suppressing the expression of inflammatory cytokines. Its cytotoxic activity involves the inhibition of angiogenesis, suppression of tumor growth, and induction of apoptosis. This comprehensive review seeks to elucidate the myriad potential effects of Gastrodin, delving into the intricate molecular mechanisms underpinning its pharmacological properties. The findings underscore the therapeutic potential of gastrodin in addressing various conditions linked to neuroinflammation and cancer.

Keywords: Gastrodin; anti-inflammatory; anticancer; apoptosis; neuroprotective.

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