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. 2024 Jul;166(1):35-43.
doi: 10.1002/ijgo.15528. Epub 2024 Apr 4.

Impact of maternal HIV infection on perinatal outcomes: A systematic review

Inioluwa Atowoju  1 , Prachi Dawer  2 , Manisha Asrani  3 , Binay Panjiyar  4
Affiliations

Impact of maternal HIV infection on perinatal outcomes: A systematic review

Inioluwa Atowoju et al. Int J Gynaecol Obstet. 2024 Jul.

Abstract

Background: Maternal HIV infection remains a significant global health concern with potential repercussions on perinatal outcomes. Emphasis on early intervention to improve peri- and postnatal outcomes in infected mothers and infants is a valid therapeutic concern.

Objectives: To comprehensively analyze perinatal outcomes associated with maternal HIV infection and evaluate adverse effects associated with the HIV infection in the existing literature.

Search strategy: A comprehensive search of PubMed, MEDLINE, and Google Scholar was conducted from 2013 to September 2023, using relevant MeSH terms.

Selection criteria: The included studies encompassed original studies, cross-sectional, prospective, retrospective studies and observational studies focused on perinatal outcomes in the context of maternal HIV infection.

Data collection and analysis: The selected studies underwent rigorous data collection and comprehensive quality checks and adhered to the PRISMA guidelines.

Main results: Nine eligible studies from Brazil, China, India, Malawi, Nigeria, Tanzania, the USA, and Canada were included. These studies have consistently demonstrated that maternal HIV infection is associated with adverse perinatal outcomes. The analysis revealed a higher risk of preterm birth (OR 1.57, 95% CI: 1.39-1.78), low birth weight (OR 1.33, 95% CI: 1.18-1.49), and small for gestational age (OR 1.38, 95% CI: 1.24-1.53) among infants born to mothers living with HIV. Notably, the impact of antiretroviral treatment (ART) on these outcomes varied, but maternal HIV infection remained a significant risk factor regardless of income level and geographic region.

Conclusion: Maternal HIV infection is consistently associated with adverse perinatal outcomes, emphasizing the need for targeted interventions and improved prenatal care in pregnant women with HIV infection.

Keywords: HIV‐infected mothers; HIV‐positive mothers; birth outcomes; maternal HIV infection; neonatal outcomes; perinatal HIV transmission; perinatal outcomes; pregnancy outcomes.

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References

REFERENCES

    1. Mother‐to‐Child Transmission of HIV. https://www.who.int/teams/global‐hiv‐hepatitis‐and‐stis‐programmes/hiv/p...
    1. UNICEF DATA. HIV Statistics—Global and Regional Trends. https://data.unicef.org/topic/hivaids/global‐regional‐trends/
    1. Shinar S, Agrawal S, Ryu M, et al. Perinatal outcomes in women living with HIV‐1 and receiving antiretroviral therapy—a systematic review and meta‐analysis. Acta Obstet Gynecol Scand. 2022 Feb;101(2):168‐182.
    1. Ndirangu J, Newell ML, Bland RM, Thorne C. Maternal HIV infection associated with small‐for‐gestational age infants but not preterm births: evidence from rural South Africa. Hum Reprod. 2012;27(6):1846‐1856.
    1. González R, Rupérez M, Sevene E, et al. Effects of HIV infection on maternal and neonatal health in southern Mozambique: a prospective cohort study after a decade of antiretroviral drugs roll out. PLoS One. 2017;12(6):e0178134.

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