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. 2024 Apr 4;19(4):e0298804.
doi: 10.1371/journal.pone.0298804. eCollection 2024.

The role of depression in the association between mobilisation timing and live discharge after hip fracture surgery: Secondary analysis of the UK National Hip Fracture Database

R Milton-Cole  1 , A Goubar  1 , S Ayis  1 , M D L O'Connell  1 , M T Kristensen  2 , F B Schuch  3   4   5 , K J Sheehan  6
Affiliations

The role of depression in the association between mobilisation timing and live discharge after hip fracture surgery: Secondary analysis of the UK National Hip Fracture Database

R Milton-Cole et al. PLoS One. .

Abstract

Purpose: The aim was to compare the probability of discharge after hip fracture surgery conditional on being alive and in hospital between patients mobilised within and beyond 36-hours of surgery across groups defined by depression.

Methods: Data were taken from the National Hip Fracture Database and included patients 60 years of age or older who underwent hip fracture surgery in England and Wales between 2014 and 2016. The conditional probability of postsurgical live discharge was estimated for patients mobilised early and for patients mobilised late across groups with and without depression. The association between mobilisation timing and the conditional probability of live discharge were also estimated separately through adjusted generalized linear models.

Results: Data were analysed for 116,274 patients. A diagnosis of depression was present in 8.31% patients. In those with depression, 7,412 (76.7%) patients mobilised early. In those without depression, 84,085 (78.9%) patients mobilised early. By day 30 after surgery, the adjusted odds ratio of discharge among those who mobilised early compared to late was 1.79 (95% CI: 1.56-2.05, p<0.001) and 1.92 (95% CI: 1.84-2.00, p<0.001) for those with and without depression, respectively.

Conclusion: A similar proportion of patients with depression mobilised early after hip fracture surgery when compared to those without a diagnosis of depression. The association between mobilisation timing and time to live discharge was observed for patients with and without depression.

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Conflict of interest statement

KS received funding from the NIHR Research for Patient Benefit, Chartered Society of Physiotherapy Charitable Trust and UKRI Future Leaders Fellowship for hip fracture health services research. RMC’s PhD studentship is funded as a host contribution to KS UKRI Future Leaders Fellowship. SA is funded by the NIHR Biomedical Research Centre based at Guy’s and St Thomas’ NHS Foundation Trust, King’s College London. MOC received funding, unrelated to this work, from the NIHR Programme Grants for Applied Research. AG, FS and MTK have no conflicts of interest to declare.

Figures

Fig 1
Fig 1. Conditional probability of live discharge by 30-days postoperatively among patients surgically treated for non-pathological first hip fracture by depression diagnosis and timing of mobilisation.
See this image and copyright information in PMC

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