Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Apr 4;19(4):e0301443.
doi: 10.1371/journal.pone.0301443. eCollection 2024.

Prevalence and risk factors of early postoperative seizures in patients with glioma: A protocol for meta-analysis and systematic review

Bo Sun  1 , Wenpeng Lu  1 , Wangyang Yu  1 , Ye Tian  1 , Peng Wang  2   1
Affiliations

Prevalence and risk factors of early postoperative seizures in patients with glioma: A protocol for meta-analysis and systematic review

Bo Sun et al. PLoS One. .

Abstract

Introduction: Early postoperative seizures has been the most common clinical expression in gliomas; however, the incidence and risk factors for early postoperative seizures in gliomas are more controversial. This protocol describes a systematic review and meta-analysis to clarify the prevalence and risk factors of early postoperative seizures in patients with glioma.

Methods and analysis: Searches will be conducted on CNKI, WanFang, VIP, PubMed, Embase, Cochrane Library databases and Web of Science for the period from database inception to December 31st, 2023. Case-control and cohort studies of the incidence and risk factors for early postoperative seizures in all gliomas will be included. The primary outcome will be incidence, risk factors. Newcastle-Ottawa Scale was used for quality evaluation. Review of article screening, extracting data and risk of bias assessment will be repeated by two independent reviewers.

Result: This study will provide evidence for the risk factors and incidence of early postoperative seizures in patients with glioma.

Conclusion: Our study will provide evidence for the prevention of early postoperative seizures in glioma patients.

Trail registration: This protocol was registered in PROSPERO and registration number is CRD42023415658.

PubMed Disclaimer

Conflict of interest statement

I have read the journal’s policy and the authors of this manuscript have the following competing interests: [The authors have declared that no competing interests exist.]

Figures

Fig 1
Fig 1. Flow diagram of the study design.
*Consider, if feasible to do so, reporting the number of records identified from each database or register searched (rather than the total number across all databases/registers). **If automation tools were used, indicate how many records were excluded by a human and how many were excluded by automation tools [36].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Fan X., Salford L.G., and Widegren B., Glioma stem cells: evidence and limitation. Semin Cancer Biol, 2007. 17(3): p. 214–8. doi: 10.1016/j.semcancer.2006.04.002 - DOI - PubMed
    1. Molinaro A.M., et al.., Genetic and molecular epidemiology of adult diffuse glioma. Nat Rev Neurol, 2019. 15(7): p. 405–417. doi: 10.1038/s41582-019-0220-2 - DOI - PMC - PubMed
    1. Li X., et al.., ZRANB2/SNHG20/FOXK1 Axis regulates Vasculogenic mimicry formation in glioma. J Exp Clin Cancer Res, 2019. 38(1): p. 68. doi: 10.1186/s13046-019-1073-7 - DOI - PMC - PubMed
    1. Ran D., et al.., All-stage precisional glioma targeted therapy enabled by a well-designed D-peptide. Theranostics, 2020. 10(9): p. 4073–4087. doi: 10.7150/thno.41382 - DOI - PMC - PubMed
    1. Li M., et al.., Tumor-derived exosomes deliver the tumor suppressor miR-3591-3p to induce M2 macrophage polarization and promote glioma progression. Oncogene, 2022. 41(41): p. 4618–4632. doi: 10.1038/s41388-022-02457-w - DOI - PMC - PubMed