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Editorial
. 2024 Jun 20;63(6):2301518.
doi: 10.1183/13993003.01518-2023. Print 2024 Jun.

Seeing pulmonary hypertension through a paediatric lens: a viewpoint

Stuti Agarwal  1 , Jeffrey Fineman  2 , David N Cornfield  3 , Cristina M Alvira  4 , Roham T Zamanian  1 , Kara Goss  5 , Ke Yuan  6 , Sebastien Bonnet  7 , Olivier Boucherat  7 , Soni Pullamsetti  8 , Miguel A Alcázar  9 , Elena Goncharova  10 , Tatiana V Kudryashova  11 , Mark R Nicolls  1 , Vinicio de Jesús Pérez  12
Affiliations
Editorial

Seeing pulmonary hypertension through a paediatric lens: a viewpoint

Stuti Agarwal et al. Eur Respir J. .

Abstract

Paediatric pulmonary hypertension (PH) offers unique genetic and developmental insights that can help in the discovery of novel mechanisms and targets to treat adult PH https://bit.ly/3TMm6bi

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Conflict of interest statement

Conflict of interest: The authors have no potential conflicts of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Mechanisms associated with the pathogenesis and evolution of paediatric pulmonary hypertension (PH) with relevance to adult PH. Prenatal factors (e.g. preeclampsia, premature birth) and genetic defects can adversely impact perinatal pulmonary vascular growth and increase susceptibility to PH with age, environmental stressors and systemic diseases. Modified from [12] with permission from the publisher.
FIGURE 2
FIGURE 2
Distribution of genetic mutations in paediatric and adult pulmonary hypertension (PH) populations. Relative contributions of de novo mutations and 18 pulmonary arterial hypertension (PAH) risk genes in a cohort of 443 paediatric and 2628 adult cases from the Columbia University Irving Medical Center and the PAH Biobank. Reproduced from [41] with permission from the publisher.
See this image and copyright information in PMC

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