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Review
. 2024 May;44(2):119-128.
doi: 10.1016/j.iac.2023.12.001. Epub 2024 Jan 9.

Pathophysiology of Eosinophilic Esophagitis

Kanak V Kennedy  1 , Amanda B Muir  2 , Melanie A Ruffner  3
Affiliations
Review

Pathophysiology of Eosinophilic Esophagitis

Kanak V Kennedy et al. Immunol Allergy Clin North Am. 2024 May.

Abstract

Eosinophilic esophagitis (EoE) is a chronic, progressive immune-mediated disease associated with antigen-driven type 2 inflammation and symptoms of esophageal dysfunction. Research over the last 2 decades has dramatically furthered our understanding of the complex interplay between genetics, environmental exposures, and cellular and molecular interactions involved in EoE. This review provides an overview of our current understanding of EoE pathogenesis.

Keywords: Eosinophil; Epithelium; Esophagitis; Etiology; Food allergy; Genetics; Pathogenesis.

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Conflict of interest statement

Disclosure The authors have declared that no conflict of interest exists for this article.

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