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Review
. 2024 May;44(2):205-221.
doi: 10.1016/j.iac.2023.12.008. Epub 2024 Jan 16.

Histopathology of Eosinophilic Esophagitis

Margaret H Collins  1 , Nicoleta C Arva  2 , Anas Bernieh  3 , Oscar Lopez-Nunez  3 , Maria Pletneva  4 , Guang-Yu Yang  5
Affiliations
Review

Histopathology of Eosinophilic Esophagitis

Margaret H Collins et al. Immunol Allergy Clin North Am. 2024 May.

Abstract

Microscopic examination of esophageal biopsies is essential to diagnose eosinophilic esophagitis (EoE). Eosinophil inflammation is the basis for the diagnosis, but additional abnormalities may contribute to persistent symptoms and epithelial barrier dysfunction. Both peak eosinophil count and assessments of additional features should be included in pre-therapy and post-therapy pathology reports. Pathologic abnormalities identified in esophageal biopsies of EoE are reversible in contrast to esophageal strictures.

Keywords: Eosinophils; Esophagus; Fibrosis; Remodeling; Smooth muscle; Stricture; Treatment.

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Conflict of interest statement

Disclosures M.H. Collins is a consultant for Allakos, Arena/Pfizer, AstraZeneca, Calypso Biotech, EsoCap Biotech, GlaxoSmithKline, Receptos/Celgene/BMS, Regeneron Pharmaceuticals, Robarts Clinical Trials Inc./Alimentiv, Inc. and Shire, a Takeda company. M. Pletneva is a consultant for Allakos. N.C. Arva, A. Bernieh, O. Lopez-Nunez and G.-Y. Yang do not have conflicts of interest.

References

Supplementary concepts