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Review
. 2024 May;42(2):433-471.
doi: 10.1016/j.ncl.2024.02.001.

The Pseudotumor Cerebri Syndrome

Deborah I Friedman  1
Affiliations
Review

The Pseudotumor Cerebri Syndrome

Deborah I Friedman. Neurol Clin. 2024 May.

Abstract

Pseudotumor cerebri syndrome is a syndrome of increased cerebrospinal fluid pressure without ventriculomegaly, mass lesion, or meningeal abnormality. It is either primary (idiopathic intracranial hypertension, IIH) or secondary. A secondary cause is unlikely when adhering to the diagnostic criteria. Permanent visual loss occurs if undetected or untreated, and the associated headaches may be debilitating. Fulminant disease may result in blindness despite aggressive treatment. This study addresses the diagnosis and management of IIH including new insights into the pathobiology of IIH, updates in therapeutics and causes of overdiagnosis.

Keywords: Idiopathic intracranial hypertension; Obesity; Optical coherence tomography; Papilledema; Pseudotumor cerebri.

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Conflict of interest statement

Disclosure Dr D.I. Friedman served on advisory boards for Abbvie, Collegium, Eli Lilly, Impel NeuroPharma, Lundbeck, Pfizer, and Zosano Pharmaand and as a speaker for Abbvie and Impel Neuropharma. She is a consultant for Pfizer. She is on the editorial board of Neurology Reviews and the Journal of Neuro-Ophthalmology, medical advisor to the Spinal CSF Leak Foundation and HealthyWomen, and on the Board of Directors of the Southern Headache Society.

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