Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 21:15:1383832.
doi: 10.3389/fneur.2024.1383832. eCollection 2024.

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

Wei Yang #  1 , Hong Dai #  1 , Xiao-Feng Xu  1 , Hai-Yin Jiang  2 , Ji-Yuan Ding  1
Affiliations

Association of atopic dermatitis and headache disorder: a systematic review and meta-analyses

Wei Yang et al. Front Neurol. .

Abstract

Background: Growing evidence suggests that headache disorders and atopic dermatitis share similar pathological mechanisms and risk factors. The aim of this study was to assess the risk for headache disorders in patients with atopic dermatitis.

Methods: We systematically searched the PubMed and Embase databases from inception to December 1, 2023, for observational studies that examined risk of migraine in subjects with atopic dermatitis. Risk estimates from individual studies were pooled using random-effects models.

Results: Ten studies with 12,717,747 subjects were included in the meta-analysis. Our results showed that patients with atopic dermatitis were associated with a higher risk of headache disorder (OR, 1.46, 95% CI = 1.36-1.56; P < 0.001; I2 = 98%) or migraine (OR, 1.32, 95% CI = 1.18-1.47; P < 0.001; I2 = 98.9%). Most of the results of the subgroup analyses were consistent with the overall results.

Conclusion: The findings of this meta-analysis suggest that atopic dermatitis is a potential risk indicator for headache disorder or migraine. Further studies are still needed to verify our findings due to the substantial heterogeneity in our analyses.

Keywords: allergic; atopic; cephalalgia; cephalgia; eczema.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow-chart of the studies considered and finally selected for review.
Figure 2
Figure 2
Forest plot of the overall risk of headache disorders in relation to AD.
Figure 3
Figure 3
Forest plot of the overall risk of Migraine in relation to AD.
See this image and copyright information in PMC

References

    1. Magis D, Schoenen J. Advances and challenges in neurostimulation for headaches. Lancet Neurol. (2012) 11:708–19. doi: 10.1016/s1474-4422(12)70139-4, PMID: - DOI - PubMed
    1. Cheema S, Mehta D, Ray JC, Hutton EJ, Matharu MS. New daily persistent headache: a systematic review and meta-analysis. Cephalalgia. (2023) 43:3331024231168089. doi: 10.1177/03331024231168089, PMID: - DOI - PubMed
    1. Tana C, Raffaelli B, Souza MNP, de la Torre ER, Massi DG, Kisani N, et al. Health equity, care access and quality in headache - part 1. J Headache Pain. (2024) 25:12. doi: 10.1186/s10194-024-01712-7, PMID: - DOI - PMC - PubMed
    1. Mitsikostas DD, Sfikakis PP, Goadsby PJ. A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth. Brain. (2004) 127:1200–9. doi: 10.1093/brain/awh146, PMID: - DOI - PubMed
    1. Dimitrova AK, Ungaro RC, Lebwohl B, Lewis SK, Tennyson CA, Green MW, et al. Prevalence of migraine in patients with celiac disease and inflammatory bowel disease. Headache. (2013) 53:344–55. doi: 10.1111/j.1526-4610.2012.02260.x, PMID: - DOI - PubMed

Publication types

LinkOut - more resources