Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 18;14(1):89702.
doi: 10.5500/wjt.v14.i1.89702.

Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

Affiliations

Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

Geisiane Custodio et al. World J Transplant. .

Abstract

Background: Prolonged donor hepatectomy time may be implicated in early and late complications of liver transplantation.

Aim: To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients, mainly early allograft dysfunction.

Methods: This multicenter retrospective study included brain-dead donors and adult liver graft recipients. Donor-recipient matching was obtained through a crossover list. Clinical and laboratory data were recorded for both donors and recipients. Donor hepatectomy, cold ischemia, and warm ischemia times were recorded. Primary outcome was early allograft dysfunction. Secondary outcomes included need for retransplantation, length of intensive care unit and hospital stay, and patient and graft survival at 12 months.

Results: From January 2019 to December 2021, a total of 243 patients underwent a liver transplant from a brain-dead donor. Of these, 57 (25%) developed early allograft dysfunction. The median donor hepatectomy time was 29 (23-40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22-38) min, whereas those without it had a median time of 30 (24-40) min (P = 0.126).

Conclusion: Donor hepatectomy time was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.

Keywords: Brain death; Early allograft dysfunction; Graft survival; Hepatectomy; Liver transplantation.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Kaplan-Meir curve illustrating the probability of graft and patient survival after liver transplantation according to donor hepatectomy time. A: Kaplan-Meir curve illustrating the probability of graft; B: Patient survival after liver transplantation according to donor hepatectomy time.

References

    1. Noguchi H, Iwanaga Y, Okitsu T, Nagata H, Yonekawa Y, Matsumoto S. Evaluation of islet transplantation from non-heart beating donors. Am J Transplant. 2006;6:2476–2482. - PubMed
    1. Armann B, Hanson MS, Hatch E, Steffen A, Fernandez LA. Quantification of basal and stimulated ROS levels as predictors of islet potency and function. Am J Transplant. 2007;7:38–47. - PMC - PubMed
    1. Banker A, Bhatt N, Rao PS, Agrawal P, Shah M, Nayak M, Mohanka R. A Review of Machine Perfusion Strategies in Liver Transplantation. J Clin Exp Hepatol. 2023;13:335–349. - PMC - PubMed
    1. Tchilikidi KY. Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion. World J Gastrointest Surg. 2019;11:126–142. - PMC - PubMed
    1. Gilbo N, Fieuws S, Meurisse N, Nevens F, van der Merwe S, Laleman W, Verslype C, Cassiman D, van Malenstein H, Roskams T, Sainz-Barriga M, Pirenne J, Jochmans I, Monbaliu D. Donor Hepatectomy and Implantation Time Are Associated With Early Complications After Liver Transplantation: A Single-center Retrospective Study. Transplantation. 2021;105:1030–1038. - PubMed