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. 2024 Mar 18;14(1):89702.
doi: 10.5500/wjt.v14.i1.89702.

Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

Geisiane Custodio  1 , Andrew Maykon Massutti  2 , Aline Caramori  2 , Taynara Gonçalves Pereira  2 , Augusto Dalazen  2 , Gabriela Scheidt  3 , Ludmilla Thomazini  4 , Cristiane Bauermann Leitão  5 , Tatiana Helena Rech  6
Affiliations

Association of donor hepatectomy time with liver transplantation outcomes: A multicenter retrospective study

Geisiane Custodio et al. World J Transplant. .

Abstract

Background: Prolonged donor hepatectomy time may be implicated in early and late complications of liver transplantation.

Aim: To evaluate the impact of donor hepatectomy time on outcomes of liver transplant recipients, mainly early allograft dysfunction.

Methods: This multicenter retrospective study included brain-dead donors and adult liver graft recipients. Donor-recipient matching was obtained through a crossover list. Clinical and laboratory data were recorded for both donors and recipients. Donor hepatectomy, cold ischemia, and warm ischemia times were recorded. Primary outcome was early allograft dysfunction. Secondary outcomes included need for retransplantation, length of intensive care unit and hospital stay, and patient and graft survival at 12 months.

Results: From January 2019 to December 2021, a total of 243 patients underwent a liver transplant from a brain-dead donor. Of these, 57 (25%) developed early allograft dysfunction. The median donor hepatectomy time was 29 (23-40) min. Patients with early allograft dysfunction had a median hepatectomy time of 25 (22-38) min, whereas those without it had a median time of 30 (24-40) min (P = 0.126).

Conclusion: Donor hepatectomy time was not associated with early allograft dysfunction, graft survival, or patient survival following liver transplantation.

Keywords: Brain death; Early allograft dysfunction; Graft survival; Hepatectomy; Liver transplantation.

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Conflict of interest statement

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Figures

Figure 1
Figure 1
Kaplan-Meir curve illustrating the probability of graft and patient survival after liver transplantation according to donor hepatectomy time. A: Kaplan-Meir curve illustrating the probability of graft; B: Patient survival after liver transplantation according to donor hepatectomy time.
See this image and copyright information in PMC

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