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Case Reports
. 2024 Mar 16;12(8):1448-1453.
doi: 10.12998/wjcc.v12.i8.1448.

Metastatic clear cell sarcoma of the pancreas: A rare case report

Yu-Jing Liu  1 , Chen Zou  2 , Yong-You Wu  3
Affiliations
Case Reports

Metastatic clear cell sarcoma of the pancreas: A rare case report

Yu-Jing Liu et al. World J Clin Cases. .

Abstract

Background: Clear cell sarcoma (CCS) is a rare soft-tissue sarcoma. The most common metastatic sites for CCS are the lungs, bones and brain. CCS is highly invasive and mainly metastasizes to the lung, followed by the bone and brain; however, pancreatic metastasis is relatively rare.

Case summary: We report on a rare case of CCS with pancreatic metastasis in a 47-year-old man. The patient had a relevant medical history 3 years ago, with abdominal pain as the main clinical manifestation. No abnormalities were observed on physical examination and the tumor was found on abdominal computed tomography. Based on the medical history and postoperative pathology, the patient was diagnosed with CCS with pancreatic metastasis. The patient was successfully treated with surgical interventions, including distal pancreatectomy and splenectomy.

Conclusion: This report summarizes the available treatment modalities for CCS and the importance of regular postoperative follow-up for patients with CCS.

Keywords: Case report; Clear cell sarcoma; Follow-up; Metastasis; Pancreas.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Abdominal computer tomograph showed a 3.2 cm × 3.0 cm round lesion in the tail of the pancreas, which was uneven and mildly enhanced under enhanced scan. A: The boundary between the posterior margin and the pancreas was not clear, and was not combined with the pancreatic duct; B: Multiple lymph nodes were also seen in the mesentery area, with the width of about 1.3 cm for the largest one.
Figure 2
Figure 2
Magnetic resonance imaging showed an abnormal blocky signal found in the pancreato-gastric space, with a size of about 3.1 cm × 2.9 cm × 2.7 cm. The boundary between the local lesion and the pancreatic body was not clear. A: T1W1 showed equal and slightly lower signal; B: T2W1 showed a slightly higher signal. The enhanced scan showed progressive uneven enhancement.
Figure 3
Figure 3
The malignant tumor of the pancreatic body was accompanied by massive necrosis. A and B: Hematoxylin and eosin (H&E) showed tumor cells arranged in nests (A; × 10), with fibrous and vascular separation around the nests (B; × 20); C: The cells were oval or polygonal, with obvious nucleoli, and some cytoplasm was lightly stained or vacuolated (H&E, × 40); D-F: No metastasis was found in the surrounding lymph nodes and no tumor involvement was found in the resection margin. Immunohistochemical results: AE1/3 (-), CD56 (-), CgA (-), CK8/18(-), HMB45(+), Melan-A (+) (D), Ki-67 (60%+), S-100 (+)(E), SOX10 (+)(F), syn (-), β-catenin (+), PR (-).
See this image and copyright information in PMC

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