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Review
. 2024 Mar 13;9(3):715-719.
doi: 10.1016/j.ncrna.2024.03.002. eCollection 2024 Sep.

Role of extracellular vesicles associated with microRNAs and their interplay with cuproptosis in osteoporosis

Yong Sun  1 , Peng Chen  2 , Bin Zhao  1
Affiliations
Review

Role of extracellular vesicles associated with microRNAs and their interplay with cuproptosis in osteoporosis

Yong Sun et al. Noncoding RNA Res. .

Abstract

Osteoporosis (OP)-associated fractures can result in severe morbidity and disability, reduced quality of life, and death. Previous studies have suggested that small noncoding RNAs, for example, small regulatory microRNAs (miRNAs), play a key role in OP by inhibiting target gene expression. Cuproptosis, a recently proposed copper-induced cell death pathway, is linked with OP. Here, we describe the contribution of exosomal miRNAs and cuproptosis to OP. First, we highlight the characteristics of exosomes and roles of exosome-related miRNAs. Next, we discuss the relationship between cuproptosis and OP. Subsequently, we analyze the crosstalk of exosomal miRNAs with cuproptosis in the development of OP. This review aims to investigate a new clinical treatment method for OP.

Keywords: Cuproptosis; Extracellular vesicles; Osteoporosis; microRNAs.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Sorting of miRNAs into EVs and their release into the cellular environment.
See this image and copyright information in PMC

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