Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2024 Mar 7;30(9):1108-1120.
doi: 10.3748/wjg.v30.i9.1108.

Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China

Ying-Yun Yang  1 , Ke-Min Li  1 , Gui-Fang Xu  2 , Cheng-Dang Wang  3 , Hua Xiong  4 , Xiao-Zhong Wang  5 , Chun-Hui Wang  6 , Bing-Yong Zhang  7 , Hai-Xing Jiang  8 , Jing Sun  9 , Yan Xu  10 , Li-Juan Zhang  11 , Hao-Xuan Zheng  12 , Xiang-Bin Xing  13 , Liang-Jing Wang  14 , Xiu-Li Zuo  15 , Shi-Gang Ding  16 , Rong Lin  17 , Chun-Xiao Chen  18 , Xing-Wei Wang  19 , Jing-Nan Li  20   21
Affiliations
Clinical Trial

Clinical manifestation, lifestyle, and treatment patterns of chronic erosive gastritis: A multicenter real-world study in China

Ying-Yun Yang et al. World J Gastroenterol. .

Abstract

Background: Although chronic erosive gastritis (CEG) is common, its clinical characteristics have not been fully elucidated. The lack of consensus regarding its treatment has resulted in varied treatment regimens.

Aim: To explore the clinical characteristics, treatment patterns, and short-term outcomes in CEG patients in China.

Methods: We recruited patients with chronic non-atrophic or mild-to-moderate atrophic gastritis with erosion based on endoscopy and pathology. Patients and treating physicians completed a questionnaire regarding history, endoscopic findings, and treatment plans as well as a follow-up questionnaire to investigate changes in symptoms after 4 wk of treatment.

Results: Three thousand five hundred sixty-three patients from 42 centers across 24 cities in China were included. Epigastric pain (68.0%), abdominal distension (62.6%), and postprandial fullness (47.5%) were the most common presenting symptoms. Gastritis was classified as chronic non-atrophic in 69.9% of patients. Among those with erosive lesions, 72.1% of patients had lesions in the antrum, 51.0% had multiple lesions, and 67.3% had superficial flat lesions. In patients with epigastric pain, the combination of a mucosal protective agent (MPA) and proton pump inhibitor was more effective. For those with postprandial fullness, acid regurgitation, early satiety, or nausea, a MPA appeared more promising.

Conclusion: CEG is a multifactorial disease which is common in Asian patients and has non-specific symptoms. Gastroscopy may play a major role in its detection and diagnosis. Treatment should be individualized based on symptom profile.

Keywords: Chronic erosive gastritis; Endoscopic findings; Real-world; Symptom; Treatment pattern.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: There are no conflicts of interest to report.

Figures

Figure 1
Figure 1
Study flow chart.
Figure 2
Figure 2
Initial symptoms and their severity. A: Symptom duration for all patients; B: Distribution of initial symptoms in all patients with gastritis; C: Distribution of symptoms innon-atrophic gastritis patients; D: Distribution of symptoms in atrophic gastritis patients.
See this image and copyright information in PMC

References

    1. Hooi JKY, Lai WY, Ng WK, Suen MMY, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VWS, Wu JCY, Chan FKL, Sung JJY, Kaplan GG, Ng SC. Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. Gastroenterology. 2017;153:420–429. - PubMed
    1. Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KE, Pritchard DM, Rugge M, Sonnenberg A, Sugano K, Tack J. The stomach in health and disease. Gut. 2015;64:1650–1668. - PMC - PubMed
    1. Du Y, Bai Y, Xie P, Fang J, Wang X, Hou X, Tian D, Wang C, Liu Y, Sha W, Wang B, Li Y, Zhang G, Shi R, Xu J, Huang M, Han S, Liu J, Ren X, Wang Z, Cui L, Sheng J, Luo H, Zhao X, Dai N, Nie Y, Zou Y, Xia B, Fan Z, Chen Z, Lin S, Li ZS Chinese Chronic Gastritis Research group. Chronic gastritis in China: a national multi-center survey. BMC Gastroenterol. 2014;14:21. - PMC - PubMed
    1. Sipponen P, Price AB. The Sydney System for classification of gastritis 20 years ago. J Gastroenterol Hepatol. 2011;26 Suppl 1:31–34. - PubMed
    1. Malfertheiner P, Peitz U. The interplay between Helicobacter pylori, gastro-oesophageal reflux disease, and intestinal metaplasia. Gut. 2005;54 Suppl 1:i13–i20. - PMC - PubMed

Supplementary concepts