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Case Reports
. 2024 Feb 18:46:92-94.
doi: 10.1016/j.jdcr.2024.02.008. eCollection 2024 Apr.

Resolution of metastatic neck nodes associated with a periauricular cutaneous squamous cell carcinoma after intranodal injection of talimogene laherparepvec

Yonglu Che  1 , Curtis Chong  2 , Marketa Limova  3 , Laura Morris  4 , Sunil Arani Reddy  4 , Anne Lynn S Chang  1
Affiliations
Case Reports

Resolution of metastatic neck nodes associated with a periauricular cutaneous squamous cell carcinoma after intranodal injection of talimogene laherparepvec

Yonglu Che et al. JAAD Case Rep. .
No abstract available

Keywords: chronic lymphocytic leukemia; cutaneous oncology; cutaneous squamous cell carcinoma; herpes; immunotherapy; metastasis; squamous cell carcinoma; talimogene laherparepvec.

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Conflict of interest statement

Dr Chang has served as a clinical investigator and consultant for Merck, Regeneron, Sun Pharma, Feldan, and Castle Biosciences. Dr Arani Reddy has served as a clinical investigator for BMS, Trisalus, and Delcath. Dr Chong has served as an advisory board member for AstraZeneca. The other authors have no conflicts of interest to declare.

Figures

Fig 1
Fig 1
Metastatic cutaneous squamous cell carcinoma before and after treatment with talimogene laherparepvec (TVEC). A, Clinical photograph before treatment with TVEC. Yellow dashed circle indicates the area of palpable lymph nodes, and periauricular ulceration with erosion of cartilage is visible. B, Yellow arrows indicate pretreatment location of positron emission tomography (PET)-avid lymph nodes. C, PET scan about 6 months after last TVEC dose indicates continued clearance of the neck nodes (no avid neck lesions). D, Clinical photograph taken about 6 months after the last injection of TVEC. Black arrows indicate areas of scout punch biopsies which showed no CSCC. Blue arrows indicate areas of granulation tissue filling in areas of prior deeper defect without clinical recurrence.
See this image and copyright information in PMC

References

    1. Note that the label states the maximum cumulative dose of 222.5 x 108 PFU has been administered in clinical studies with no evidence of dose-limiting toxicity (page 12, section 10 “Overdosage”) https://www.fda.gov/media/94129/download
    1. Nguyen T.A., Offner M., Hamid O., Zumsteg Z.S., Gharavi N.M. Complete and sustained remission of metastatic cutaneous squamous cell carcinoma in a liver transplant patient treated with talimogene laherparepvec. Dermatol Surg. 2021;47(6):820–822. - PubMed
    1. Franke V., Stahlie E.H.A., Klop W.M.C., et al. Talimogene laherparepvec monotherapy for head and neck melanoma patients. Melanoma Res. 2023;33(1):66–70. - PubMed

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