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Review
. 2024 Jun;239(6):e31265.
doi: 10.1002/jcp.31265. Epub 2024 Apr 5.

Adipose tissue plasticity mediated by the counterregulatory axis of the renin-angiotensin system: Role of Mas and MrgD receptors

Ana Beatriz Proença  1   2 , Gabriela Rodrigues Medeiros  1   2 , Guilherme Dos Santos Reis  1   2 , Luiza da França Losito  1   2 , Luiza Mazzali Ferraz  1   2 , Thereza Cristina Lonzetti Bargut  3 , Nícia Pedreira Soares  4 , Beatriz Alexandre-Santos  1   2 , Maria Jose Campagnole-Santos  4 , D'Angelo Carlo Magliano  2 , Antonio Claudio Lucas da Nobrega  1 , Robson Augusto Souza Santos  4 , Eliete Dalla Corte Frantz  1   2
Affiliations
Review

Adipose tissue plasticity mediated by the counterregulatory axis of the renin-angiotensin system: Role of Mas and MrgD receptors

Ana Beatriz Proença et al. J Cell Physiol. 2024 Jun.

Abstract

The renin-angiotensin system (RAS) is an endocrine system composed of two main axes: the classical and the counterregulatory, very often displaying opposing effects. The classical axis, primarily mediated by angiotensin receptors type 1 (AT1R), is linked to obesity-associated metabolic effects. On the other hand, the counterregulatory axis appears to exert antiobesity effects through the activation of two receptors, the G protein-coupled receptor (MasR) and Mas-related receptor type D (MrgD). The local RAS in adipose organ has prompted extensive research into white adipose tissue and brown adipose tissue (BAT), with a key role in regulating the cellular and metabolic plasticity of these tissues. The MasR activation favors the brown plasticity signature in the adipose organ by improve the thermogenesis, adipogenesis, and lipolysis, decrease the inflammatory state, and overall energy homeostasis. The MrgD metabolic effects are related to the maintenance of BAT functionality, but the signaling remains unexplored. This review provides a summary of RAS counterregulatory actions triggered by Mas and MrgD receptors on adipose tissue plasticity. Focus on the effects related to the morphology and function of adipose tissue, especially from animal studies, will be given targeting new avenues for treatment of obesity-associated metabolic effects.

Keywords: Mas receptor; MrgD receptor; beige adipocytes; brown adipose tissue (BAT); renin‐angiotensin system (RAS); white adipose tissue (WAT).

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References

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