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. 2024 Oct 1;25(4):978-996.
doi: 10.1093/biostatistics/kxae011.

Identification of complier and noncomplier average causal effects in the presence of latent missing-at-random (LMAR) outcomes: a unifying view and choices of assumptions

Trang Quynh Nguyen  1 , Michelle C Carlson  1 , Elizabeth A Stuart  1   2   3
Affiliations

Identification of complier and noncomplier average causal effects in the presence of latent missing-at-random (LMAR) outcomes: a unifying view and choices of assumptions

Trang Quynh Nguyen et al. Biostatistics. .

Erratum in

  • Correction.
    [No authors listed] [No authors listed] Biostatistics. 2024 Dec 31;26(1):kxae029. doi: 10.1093/biostatistics/kxae029. Biostatistics. 2024. PMID: 39186534 Free PMC article. No abstract available.

Abstract

The study of treatment effects is often complicated by noncompliance and missing data. In the one-sided noncompliance setting where of interest are the complier and noncomplier average causal effects, we address outcome missingness of the latent missing at random type (LMAR, also known as latent ignorability). That is, conditional on covariates and treatment assigned, the missingness may depend on compliance type. Within the instrumental variable (IV) approach to noncompliance, methods have been proposed for handling LMAR outcome that additionally invoke an exclusion restriction-type assumption on missingness, but no solution has been proposed for when a non-IV approach is used. This article focuses on effect identification in the presence of LMAR outcomes, with a view to flexibly accommodate different principal identification approaches. We show that under treatment assignment ignorability and LMAR only, effect nonidentifiability boils down to a set of two connected mixture equations involving unidentified stratum-specific response probabilities and outcome means. This clarifies that (except for a special case) effect identification generally requires two additional assumptions: a specific missingness mechanism assumption and a principal identification assumption. This provides a template for identifying effects based on separate choices of these assumptions. We consider a range of specific missingness assumptions, including those that have appeared in the literature and some new ones. Incidentally, we find an issue in the existing assumptions, and propose a modification of the assumptions to avoid the issue. Results under different assumptions are illustrated using data from the Baltimore Experience Corps Trial.

Keywords: exclusion restriction; latent ignorability; latent missing at random; missing outcome; principal ignorability; principal stratification.

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