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Case Reports
. 1985 Jun 15;55(12):2845-9.
doi: 10.1002/1097-0142(19850615)55:12<2845::aid-cncr2820551223>3.0.co;2-j.

Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy

S Hisa, S Morinaga, Y Kobayashi, M Ojima, H Chikaoka, N Sasano
Case Reports

Intramedullary spinal cord germinoma producing HCG and precocious puberty in a boy

S Hisa et al. Cancer. .

Abstract

Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologically, the tumor showed germinoma with syncytiotrophoblastic giant cells. The tumor remitted for 5 months after irradiation of 3500 rad and chemotherapy, but recurred in spite of adding 7500 rad and more aggressive chemotherapy. No relapse has been seen for 1 year after amputation of the spinal cord at the T7 level.

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