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Comment
. 2024 Apr 4;12(4):e008937.
doi: 10.1136/jitc-2024-008937.

Targeting of netrin-1 by monoclonal antibody NP137 inhibits the EMT in cancer

Xueli Xia  1   2 , Kai Yin  3 , Shengjun Wang  4   2
Affiliations
Comment

Targeting of netrin-1 by monoclonal antibody NP137 inhibits the EMT in cancer

Xueli Xia et al. J Immunother Cancer. .
No abstract available

Keywords: Immunotherapy.

PubMed Disclaimer

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Pharmacological targeting of netrin-1 by NP137 inhibits the EMT and cancer progression. NP137 administration in patients with endometrial cancer or a primary mouse model decreased EMT scores and increased tumour cell apoptosis, as well as changing immune cell infiltration and increasing the strength of the interaction between antigen-presenting cells and tumor cells, which led to tumor inhibition. Moreover, NP137 can improve the tumor-killing effects of chemotherapy drugs such as carboplatin-paclitaxel. CAF, cancer-associated fibroblast; EMT, epithelial-mesenchymal transition; NK, natural killer; SCC, skin squamous cell carcinoma; Treg, regulatory T cell.
See this image and copyright information in PMC

Comment on

  • Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer.
    Cassier PA, Navaridas R, Bellina M, Rama N, Ducarouge B, Hernandez-Vargas H, Delord JP, Lengrand J, Paradisi A, Fattet L, Garin G, Gheit H, Dalban C, Pastushenko I, Neves D, Jelin R, Gadot N, Braissand N, Léon S, Degletagne C, Matias-Guiu X, Devouassoux-Shisheboran M, Mery-Lamarche E, Allard J, Zindy E, Decaestecker C, Salmon I, Perol D, Dolcet X, Ray-Coquard I, Blanpain C, Bernet A, Mehlen P. Cassier PA, et al. Nature. 2023 Aug;620(7973):409-416. doi: 10.1038/s41586-023-06367-z. Epub 2023 Aug 2. Nature. 2023. PMID: 37532934 Free PMC article. Clinical Trial.

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