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. 2024 Jun;309(6):2881-2890.
doi: 10.1007/s00404-024-07473-7. Epub 2024 Apr 5.

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients' basal vitamin D status

Giorgio Maria Baldini  1 , Michele Russo  2 , Sara Proietti  3 , Gianpiero Forte  3 , Domenico Baldini  1 , Giuseppe Trojano  4
Affiliations

Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients' basal vitamin D status

Giorgio Maria Baldini et al. Arch Gynecol Obstet. 2024 Jun.

Erratum in

Abstract

Purpose: The study aims to demonstrate the effects of Vitamin D (VD) supplementation, prior to oocyte pick-up within IVF protocols, in women with diverse VD status at the enrollment.

Methods: A total of 204 women eligible for intra-cytoplasmatic sperm injection (ICSI) cycles were included in the study and two homogeneous groups were selected from the database. Both group of patients with normal VD baseline level (> 40 ng/ml) and patients with low VD baseline level (< 20 ng/ml) were divided into control group and treatment group. The control group followed the standard procedure. The treatment group was supplemented with vitamin D3 as cholecalciferol in combination with Myo-Inositol, folic acid, and melatonin 3 months before standard procedure, once a day in the evening.

Results: VD levels significantly increased in the study group of low baseline VD, both in serum and in the follicular fluid compared to controls. The treatment induced a significant improvement of the embryo quality in both group of patients considered.

Conclusion: Supplementation of VD in patients undergoing ICSI procedures significantly improved the number of top-quality embryos compared with the control group, either starting from VD normal baseline values or starting from low values.

Trial registration number: 07/2018.

Keywords: Embryo quality; Endometrial thickness; ICSI; IVF outcomes; Progesterone levels; Vitamin D.

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Conflict of interest statement

M. R., S. P., G. F. are employees of Lo.Li. pharma s.r.l.

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