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. 2024 Apr 5;24(1):130.
doi: 10.1186/s12871-024-02474-0.

Skin mottling score assesses peripheral tissue hypoperfusion in critically ill patients following cardiac surgery

Jing-Chao Luo #  1   2 , Ming-Hao Luo #  1   3 , Yi-Jie Zhang #  1 , Wen-Jun Liu  1 , Guo-Guang Ma  1 , Jun-Yi Hou  1 , Ying Su  1 , Guang-Wei Hao  1 , Guo-Wei Tu  4 , Zhe Luo  5
Affiliations

Skin mottling score assesses peripheral tissue hypoperfusion in critically ill patients following cardiac surgery

Jing-Chao Luo et al. BMC Anesthesiol. .

Abstract

Background: Skin mottling is a common manifestation of peripheral tissue hypoperfusion, and its severity can be described using the skin mottling score (SMS). This study aims to evaluate the value of the SMS in detecting peripheral tissue hypoperfusion in critically ill patients following cardiac surgery.

Methods: Critically ill patients following cardiac surgery with risk factors for tissue hypoperfusion were enrolled (n = 373). Among these overall patients, we further defined a hypotension population (n = 178) and a shock population (n = 51). Hemodynamic and perfusion parameters were recorded. The primary outcome was peripheral hypoperfusion, defined as significant prolonged capillary refill time (CRT, > 3.0 s). The characteristics and hospital mortality of patients with and without skin mottling were compared. The area under receiver operating characteristic curves (AUROC) were used to assess the accuracy of SMS in detecting peripheral hypoperfusion. Besides, the relationships between SMS and conventional hemodynamic and perfusion parameters were investigated, and the factors most associated with the presence of skin mottling were identified.

Results: Of the 373-case overall population, 13 (3.5%) patients exhibited skin mottling, with SMS ranging from 1 to 5 (5, 1, 2, 2, and 3 cases, respectively). Patients with mottling had lower mean arterial pressure, higher vasopressor dose, less urine output (UO), higher CRT, lactate levels and hospital mortality (84.6% vs. 12.2%, p < 0.001). The occurrences of skin mottling were higher in hypotension population and shock population, reaching 5.6% and 15.7%, respectively. The AUROC for SMS to identify peripheral hypoperfusion was 0.64, 0.68, and 0.81 in the overall, hypotension, and shock populations, respectively. The optimal SMS threshold was 1, which corresponded to specificities of 98, 97 and 91 and sensitivities of 29, 38 and 67 in the three populations (overall, hypotension and shock). The correlation of UO, lactate, CRT and vasopressor dose with SMS was significant, among them, UO and CRT were identified as two major factors associated with the presence of skin mottling.

Conclusion: In critically ill patients following cardiac surgery, SMS is a very specific yet less sensitive parameter for detecting peripheral tissue hypoperfusion.

Keywords: Capillary refill time; Cardiac surgery; Shock; Skin mottling; Tissue hypoperfusion.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Occurrences of skin mottling in different populations (A), ROC curves for SMS to identify peripheral hypoperfusion (B) and predict hospital mortality (C) ROC: receiver operator characteristic curve
Fig. 2
Fig. 2
The survival curves for patients with and without skin mottling
See this image and copyright information in PMC

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