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. 2024 Apr 30;42(12):2951-2954.
doi: 10.1016/j.vaccine.2024.04.011. Epub 2024 Apr 6.

Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination

Chia-Yin Chong  1 , Kai-Qian Kam  2 , Jinyan Zhang  3 , Antonio Bertoletti  3 , Smrithi Hariharaputran  3 , Rehena Sultana  4 , Rupini Piragasam  5 , Yun-Yan Mah  3 , Chee-Wah Tan  6 , Linfa Wang  3 , Chee-Fu Yung  7
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Immunogenicity and safety of Sinovac-CoronaVac booster vaccinations in 12-17- year-olds with clinically significant reactions from Pfizer-BNT162b2 vaccination

Chia-Yin Chong et al. Vaccine. .

Abstract

Heterologous Sinovac-CoronaVac booster(s) in 12-17-year-olds who had a moderate/severe reaction to Pfizer-BNT162b2 mRNA vaccine was found to safe with no serious adverse events reported. In those primed with 1 dose of Pfizer-BNT162b2 vaccine, subsequent boosters with 2 doses of Sinovac-CoronaVac vaccines achieved neutralizing antibody levels which were comparable to those who had received 2 doses of Pfizer-BNT162b2 vaccines followed by 1 dose of Sinovac-CoronaVac vaccination. Adolescents with 1 Pfizer-BNT162b2 followed by 2 Sinovac-CoronaVac vaccines developed T-cell responses against broad peptides including membrane, nucleoprotein 1 and 2 but levels were highest for Spike protein and lasted until day 150 post-vaccination.

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Conflict of interest statement

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Chia-Yin CHong reports financial support was provided by Government of Singapore Ministry of Health. Chee-Fu Yung reports financial support was provided by National Medical Research Council.].

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