Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Mar 26;80(Pt 4):392-395.
doi: 10.1107/S2056989024002573. eCollection 2024 Mar 1.

Synthesis and crystal structure of N-phenyl-2-(phenyl-sulfan-yl)acetamide

Reham A Mohamed-Ezzat  1 , Benson M Kariuki  2 , Galal H Elgemeie  3
Affiliations

Synthesis and crystal structure of N-phenyl-2-(phenyl-sulfan-yl)acetamide

Reham A Mohamed-Ezzat et al. Acta Crystallogr E Crystallogr Commun. .

Abstract

N-Phenyl-2-(phenyl-sulfan-yl)acetamide, C14H13NOS, was synthesized and structurally characterized. In the crystal, N-H⋯O hydrogen bonding leads to the formation of chains of mol-ecules along the [100] direction. The chains are linked by C-H⋯π inter-actions, forming a three-dimensional network. The crystal studied was twinned by a twofold rotation around [100].

Keywords: acetamide; crystal structure; sulfide; synthesis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The asymmetric unit and mol­ecular structures of the two independent mol­ecules of N-phenyl-2-(phenyl­sulfan­yl)acetamide (3) showing displacement ellipsoids at the 50% probability level.
Figure 2
Figure 2
(a) Crystal packing in the crystal structure of N-phenyl-2-(phenyl­sulfan­yl)acetamide (3). (b) A segment of the crystal structure of compound 3 showing the N—H⋯O and C—H⋯π inter­molecular contacts as green dotted lines.
Figure 3
Figure 3
The synthesis of compound 3 from sulfonyl­guanidine.
See this image and copyright information in PMC

References

    1. Agrawal, R., Rewatkar, P. V., Kokil, G. R., Verma, A. & Kalra, A. (2010). Med. Chem. 6, 247–251. - PubMed
    1. Bruno, I. J., Cole, J. C., Edgington, P. R., Kessler, M., Macrae, C. F., McCabe, P., Pearson, J. & Taylor, R. (2002). Acta Cryst. B58, 389–397. - PubMed
    1. Elgemeie, G. H., Alkhursani, S. A. & Mohamed, R. A. (2019). Nucleosides Nucleotides Nucleic Acids, 38, 1–11. - PubMed
    1. Elgemeie, G. H., Mohamed, R. A., Hussein, H. A. & Jones, P. G. (2015). Acta Cryst. E71, 1322–1324. - PMC - PubMed
    1. Elgemeie, G. H. & Mohamed-Ezzat, R. A. (2022). New Strategies Targeting Cancer Metabolism, pp. 1–619. Amsterdam: Elsevier. ISBN: 978-0-12-821783-2.

LinkOut - more resources