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. 2024 Mar 20:4:102791.
doi: 10.1016/j.bas.2024.102791. eCollection 2024.

Assessing the impact of distortion correction on Gamma Knife radiosurgery for multiple metastasis: Volumetric and dosimetric analysis

Yavuz Samanci  1   2 , M Orbay Askeroglu  2 , Ali Haluk Düzkalir  2   3 , Selcuk Peker  1   2
Affiliations

Assessing the impact of distortion correction on Gamma Knife radiosurgery for multiple metastasis: Volumetric and dosimetric analysis

Yavuz Samanci et al. Brain Spine. .

Abstract

Introduction: Magnetic resonance imaging (MRI) is a robust neuroimaging technique and is the preferred method for stereotactic radiosurgery (SRS) planning. However, MRI data always contain distortions caused by hardware and patient factors.

Research question: Can these distortions potentially compromise the effectiveness and safety of SRS treatments?

Material and methods: Twenty-six MR datasets with multiple metastatic brain tumors (METs) used for Gamma Knife radiosurgery (GKRS) were retrospectively evaluated. A commercially available software was used for distortion correction. Geometrical agreement between corrected and uncorrected tumor volumes was evaluated using MacDonald criteria, Euclidian distance, and Dice similarity coefficient (DSC). SRS plans were generated using uncorrected tumor volumes, which were assessed to determine their coverage of the corrected tumor volumes.

Results: The median target volume was 0.38 cm3 (range,0.01-12.38 cm3). A maximum displacement of METs of up to 2.87 mm and a median displacement of 0.55 mm (range,0.1-2.87 mm) were noted. The median DSC between uncorrected and corrected MRI was 0.92, and the most concerning case had a DSC of 0.46. Although all plans met the optimization criterion of at least 98% of the uncorrected tumor volume (median 99.55%, range 98.1-100%) receiving at least 100% of the prescription dose, the percent of the corrected tumor volume receiving the total prescription dose was a median of 95.45% (range,23.1-99.5%).

Discussion and conclusion: MRI distortion, though visually subtle, has significant implications for SRS planning. Regular utilization of corrected MRI is recommended for SRS planning as distortion is sometimes enough to cause a volumetric miss of SRS targets.

Keywords: Displacement; Distortion; Gamma Knife radiosurgery; Magnetic resonance imaging; Metastatic brain tumors.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
The Distortion Correction application providing a visual representation of the distortion map (right side) after correcting an MR dataset (left side).
Fig. 2
Fig. 2
Figure provides axial, sagittal, and coronal views that depict the original target volume (green contour) and its corresponding corrected target volume (red contour).
Fig. 3
Fig. 3
Corrected tumor volume is outlined in green, and uncorrected tumor volume is outlined in yellow. The displacement of the center of mass is 1.4 mm and the Dice similarity coefficient is 0.57. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Fig. 4
Fig. 4
Violin-plot showing planning and corrected coverage according to volume subgroups.
See this image and copyright information in PMC

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