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. 2024 Apr;106(4):225-230.
doi: 10.4174/astr.2024.106.4.225. Epub 2024 Mar 29.

Clinical characteristics of choledochal cysts with intrahepatic bile duct dilatations: an observational study

Ken Chen  1 , Shuhao Zhang  1 , Duote Cai  1 , Yuebin Zhang  1 , Yi Jin  1 , Wenjuan Luo  1 , Zongwei Huang  1 , Di Hu  1 , Zhigang Gao  1
Affiliations

Clinical characteristics of choledochal cysts with intrahepatic bile duct dilatations: an observational study

Ken Chen et al. Ann Surg Treat Res. 2024 Apr.

Abstract

Purpose: Whether a dilated intrahepatic bile duct (IHBD) has any effect on the prognosis of choledochal cyst (CC) remains controversial. We aimed to summarize the clinical characteristics and prognosis of CC with IHBD dilatation.

Methods: One hundred ninety-two children diagnosed with CC were identified, including 127 without IHBD dilatation (group A) and 65 with IHBD dilatation (group B). A retrospective analysis was performed to explore the clinical characteristics and prognosis of CC with IHBD dilatation based on clinical indices, symptoms, and complications.

Results: Compared with group A, incidences of jaundice and fever were higher in group B (P = 0.010 and P = 0.033). Preoperative total bilirubin, direct bilirubin, and indirect bilirubin were increased in group B compared to group A (P = 0.005, P < 0.001, and P = 0.014), as were preoperative ALT, AST, γ-GT, and total bile acid (P = 0.006, P = 0.025, P < 0.001, and P = 0.024). The risk of liver fibrosis or cirrhosis was significantly increased for group B compared with group A (P = 0.012) and also occurred earlier in group B (P = 0.006). In the dilated IHBDs, 95.4% (62 of 65) recovered to normal, and more than half of dilated IHBDs (37 of 65) recovered to normal in 1 week.

Conclusion: Most IHBDs can recover to normal postoperatively in a short time, and proactive treatment is recommended for CC patients with IHBD dilatation for significant abnormal liver functions.

Keywords: Choledochal cyst; Dilatation; Extrahepatic bile ducts; Intrahepatic bile ducts.

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Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1
Fig. 1. Prognostic analyses of choledochal cyst patients with or without intrahepatic bile duct dilatation. Kaplan-Meier analysis of liver fibrosis- or cirrhosis-free survival for group A (high) and group B (low) was analyzed. Log-rank test was used.
Fig. 2
Fig. 2. Preoperative (A) and postoperative (B) magnetic resonance cholangiopancreatography images of a patient with intrahepatic bile duct (IHBD) dilatation. The images were gained on May 30, 2017 and May 12, 2020, respectively. The red arrowheads point to the IHBD.
See this image and copyright information in PMC

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References

    1. Matsumoto M, Urushihara N, Fukumoto K, Yamoto M, Miyake H, Nakajima H. Laparoscopic management for prenatally diagnosed choledochal cysts. Surg Today. 2016;46:1410–1414. - PubMed
    1. Koshinaga T, Inoue M, Ohashi K, Sugito K, Ikeda T, Hagiwara N, et al. Persistent biliary dilatation and stenosis in postoperative congenital choledochal cyst. J Hepatobiliary Pancreat Sci. 2011;18:47–52. - PubMed
    1. Congo K, Lopes MF, Oliveira PH, Matos H, Basso S, Reis A. Outcomes of choledochal cysts with or without intrahepatic involvement in children after extrahepatic cyst excision and Roux-en-Y hepaticojejunostomy. Ann Hepatol. 2012;11:536–543. - PubMed
    1. Saluja SS, Nayeem M, Sharma BC, Bora G, Mishra PK. Management of choledochal cysts and their complications. Am Surg. 2012;78:284–290. - PubMed
    1. Fujishiro J, Masumoto K, Urita Y, Shinkai T, Gotoh C. Pancreatic complications in pediatric choledochal cysts. J Pediatr Surg. 2013;48:1897–1902. - PubMed