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Review
. 2024 Jul;36(7):e13385.
doi: 10.1111/jne.13385. Epub 2024 Apr 8.

The prolactin receptor: A cross-species comparison of gene structure, transcriptional regulation, tissue-specificity, and genetic variation

Carmen M Banks  1 , Josephine F Trott  1 , Russell C Hovey  1
Affiliations
Review

The prolactin receptor: A cross-species comparison of gene structure, transcriptional regulation, tissue-specificity, and genetic variation

Carmen M Banks et al. J Neuroendocrinol. 2024 Jul.

Abstract

The conserved and multifaceted functions of prolactin (PRL) are coordinated through varied distribution and expression of its cell-surface receptor (PRLR) across a range of tissues and physiological states. The resultant heterogeneous expression of PRLR mRNA and protein across different organs and cell types supports a wide range of PRL-regulated processes including reproduction, lactation, development, and homeostasis. Genetic variation within the PRLR gene also accounts for several phenotypes impacting agricultural production and human pathology. The goal of this review is to highlight the many elements that control differential expression of the PRLR across tissues, and the various phenotypes that exist across species due to variation in the PRLR gene.

Keywords: allele‐specific expression; alternative promoters; alternative splicing; gene regulation; mutations.

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References

REFERENCES

    1. Stricker P, Grueter R. Action du lobe anterieur de l'hypophyse sur la montee laiteuse. C R Soc Biol. 1928;99(38):1978‐1980.
    1. Riddle O, Bates R, Dykshorn S. The preparation, identification and assay of prolactin—a hormone of the anterior pituitary. Am J Physiol. 1933;105:191‐216.
    1. Bole‐Feysot C, Goffin V, Edery M, Binart N, Kelly PA. Prolactin (PRL) and its receptor: actions, signal transduction pathways and phenotypes observed in PRL receptor knockout mice. Endocr Rev. 1998;19(3):225‐268.
    1. Kato K, Ikemoto T, Park MK. Identification of the reptilian prolactin and its receptor cDNAs in the leopard gecko, Eublepharis macularius. Gene. 2005;346:267‐276.
    1. Wang J, Hou SS, Huang W, Yang XG, Zhu XY, Liu XL. Molecular cloning of prolactin receptor of the Peking duck. Poult Sci. 2009;88(5):1016‐1022.

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