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Editorial
. 2024 Apr 9;149(15):1202-1204.
doi: 10.1161/CIRCULATIONAHA.124.067882. Epub 2024 Apr 8.

Hemodynamic Forces and Atherosclerosis: HEG1 at the Center of the Jigsaw Puzzle

M Luisa Iruela-Arispe  1
Affiliations
Editorial

Hemodynamic Forces and Atherosclerosis: HEG1 at the Center of the Jigsaw Puzzle

M Luisa Iruela-Arispe. Circulation. .
No abstract available

Keywords: Editorials; HEG1 protein, human; KLF2 protein, human; endothelial cells; hemodynamics; plaque, atherosclerotic; shear stress.

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Conflict of interest statement

Disclosures None.

Figures

Figure 1
Figure 1. HEG1 protein interactions and signaling under disturbed and laminar shear stress.
Under disturbed shear stress HEG1 remains bound to KRIT1 and does not enable activation of the MEKK3 pathway. In contrast, under laminar shear stress, HEG1 localizes downstream in the endothelial cells and is shed into the circulation along with its binding partner, KRIT. The mechanism by which these two proteins are shed is not understood. This results in intracellular activation of CCM2 and CCM3, leading to activation of the MEKK3 cascade with eventual upregulation of KLF2 and KLF4. These flow-induced transcription factors then lead to transcription of downstream targets.
See this image and copyright information in PMC

Comment on

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