Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun:195:110273.
doi: 10.1016/j.radonc.2024.110273. Epub 2024 Apr 7.

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines

Raquel Dávila Fajardo  1 , Giovanni Scarzello  2 , Mark N Gaze  3 , Tom Boterberg  4 , Alison Cameron  5 , Joerg Fuchs  6 , Florent Guérin  7 , Peter Hoskin  8 , Matthew J Krasin  9 , Petra Kroon  10 , Henriette Magelssen  11 , Claes Mercke  12 , Johannes H M Merks  13 , Frank Paulsen  14 , Pascal Pommier  15 , Monica Ramos  16 , Helen Rees  17 , Tim Rogers  18 , Maximilian Schmid  19 , Guido Seitz  20 , Olga Slater  21 , Naima Smeulders  22 , Jakob Stenman  23 , Sheila Terwisscha  24 , Cyrus Chargari  25 , Henry C Mandeville  26
Affiliations
Free article

Brachytherapy for rhabdomyosarcoma: Survey of international clinical practice and development of guidelines

Raquel Dávila Fajardo et al. Radiother Oncol. 2024 Jun.
Free article

Abstract

Background and purpose: The purpose of this study was to address the lack of published data on the use of brachytherapy in pediatric rhabdomyosarcoma by describing current practice as starting point to develop consensus guidelines.

Materials and methods: An international expert panel on the treatment of pediatric rhabdomyosarcoma comprising 24 (pediatric) radiation oncologists, brachytherapists and pediatric surgeons met for a Brachytherapy Workshop hosted by the European paediatric Soft tissue Sarcoma Study Group (EpSSG). The panel's clinical experience, the results of a previously distributed questionnaire, and a review of the literature were presented.

Results: The survey indicated the most common use of brachytherapy to be in combination with tumor resection, followed by brachytherapy as sole local therapy modality. HDR was increasingly deployed in pediatric practice, especially for genitourinary sites. Brachytherapy planning was mostly by 3D imaging based on CT. Recommendations for patient selection, treatment requirements, implant technique, delineation, dose prescription, dose reporting and clinical management were defined.

Conclusions: Consensus guidelines for the use of brachytherapy in pediatric rhabdomyosarcoma have been developed through multicenter collaboration establishing the basis for future work. These have been adopted for the open EpSSG overarching study for children and adults with Frontline and Relapsed RhabdoMyoSarcoma (FaR-RMS).

Keywords: Brachytherapy; Rhabdomyosarcoma; Soft Tissue Sarcoma.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Conflicts of interest Dr. Mark N. Gaze is supported by the National Institute for Health Research University College London Hospitals Biomedical Research Centre and by the Radiation Research Unit at the Cancer Research UK City of London Centre Award [C7893/A28990]. Prof. Dr. Peter Hoskin is supported by the NIHR Manchester Biomedical Centre. Dr. Henry C. Mandeville is supported by the National Institute for Health Research Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research.

LinkOut - more resources