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Review
. 2024 Apr 1:40:100892.
doi: 10.1016/j.lanepe.2024.100892. eCollection 2024 May.

Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)

Marianne Leruez-Ville  1   2 , Christos Chatzakis  3   4 , Daniele Lilleri  5 , Daniel Blazquez-Gamero  6 , Ana Alarcon  7 , Nicolas Bourgon  3 , Ina Foulon  8 , Jacques Fourgeaud  1   2 , Anna Gonce  9 , Christine E Jones  10 , Paul Klapper  11 , André Krom  12 , Tiziana Lazzarotto  13   14 , Hermione Lyall  15 , Paulo Paixao  16 , Vassiliki Papaevangelou  17 , Elisabeth Puchhammer  18 , George Sourvinos  19 , Pamela Vallely  11 , Yves Ville  1   3 , Ann Vossen  20
Affiliations
Review

Consensus recommendation for prenatal, neonatal and postnatal management of congenital cytomegalovirus infection from the European congenital infection initiative (ECCI)

Marianne Leruez-Ville et al. Lancet Reg Health Eur. .

Erratum in

Abstract

Congenital cytomegalovirus (cCMV) infection carries a significant burden with a 0.64% global prevalence and a 17-20% chance of serious long-term effects in children. Since the last guidelines, our understanding, particularly regarding primary maternal infections, has improved. A cCMV guidelines group was convened under the patronage of the European Society of Clinical Virology in April 2023 to refine these insights. The quality and validity of selected studies were assessed for potential biases and the GRADE framework was employed to evaluate quality of evidence across key domains. The resulting recommendations address managing cCMV, spanning prevention to postnatal care. Emphasizing early and accurate maternal diagnosis through serological tests enhances risk management and prevention strategies, including using valaciclovir to prevent vertical transmission. The guidelines also strive to refine personalized postnatal care based on risk assessments, ensuring targeted interventions for affected families.

Keywords: Congenital cytomegalovirus infection; Guidelines; Neonatal; Postnatal; Prenatal.

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Conflict of interest statement

MLV reports receiving support for attending meetings by BioMérieux and Altona outside the submitted work. MLV reports payment made to her institution for presentation/lecture by Diasorin, Abbott Molecular and Roche Diagnostic outside the submitted work. DBG received Grant from the Spanish Ministry of Science and Innovation. ISCIII and Fondos FEDER (EU) outside the submitted work and received Honoraria for lectures from the Medscape, outside the submitted work. JF received honoraria for poster presentation by Abbott GmbH, outside the submitted work. CJ received consulting fees from Moderna, outside the submitted work; Participated on a Data Safety Monitoring Board or Advisory Board of Moderna, outside the submitted work; Is Co-director of the European Congenital CMV Initiative; Her institution received payment for clinical trials by Moderna, outside the submitted work. HL participated on advisory board for the Study of Zidovudine in children with Aicadri-Goutiere Syndrome, outside the submitted work and she is Trustee of European Society For Paediatric Infectious Diseases (ESPID). VP institution received honoraria for lectures from MSD and Pfizer, outside the submitted work and received support for attending a meeting (ESPID 2023) from Pfizer. PV is president and board-member of the European Congenital CMV Initiative. AV is participating in the Advisory Council European Society of Virology. The rest author of the authors declare no conflict of interest.

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