Biomarker challenges in the pursuit of personalized neoadjuvant chemotherapy for muscle-invasive bladder cancer: conclusions from SWOG S1314
- PMID: 38590957
- PMCID: PMC10999026
- DOI: 10.21037/tau-23-620
Biomarker challenges in the pursuit of personalized neoadjuvant chemotherapy for muscle-invasive bladder cancer: conclusions from SWOG S1314
Keywords: Bladder neoplasms; CO-eXpression ExtrapolatioN (COXEN); biomarkers; neoadjuvant therapy; tumor.
Conflict of interest statement
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tau.amegroups.com/article/view/10.21037/tau-23-620/coif). M.P.S.L. has received honoraria from Bayer and EMD Serono and is an unpaid research collaborator for Veracyte, all outside of the present manuscript. P.B. has received consulting fees for AbbVie, AstraZeneca, Astellas, Bayer, BMS, Combat, EMD-Serono, Ferring, Janssen, Merck, Nonagen, Nanobot, NanOlogy, Pfizer, Photocure, Prokarium, Sumitomo, TerSera, Tolmar, and Verity; has received honoraria from Janssen, TerSera, Bayer, and Pfizer; and shares patent with Veracyte. The other author has no conflicts of interest to declare.
Comment on
-
Long-term Outcomes from a Phase 2 Study of Neoadjuvant Chemotherapy for Muscle-invasive Bladder Cancer (SWOG S1314; NCT02177695).Eur Urol. 2023 Sep;84(3):341-347. doi: 10.1016/j.eururo.2023.06.014. Epub 2023 Jul 4. Eur Urol. 2023. PMID: 37414705 Free PMC article. Clinical Trial.
Similar articles
-
Review of SWOG S1314: Lessons from a Randomized Phase II Study of Co-Expression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Localized, Muscle-Invasive Bladder Cancer.Bladder Cancer. 2020 Jun 11;6(2):123-129. doi: 10.3233/BLC-190266. Bladder Cancer. 2020. PMID: 32793789 Free PMC article. Review.
-
A Randomized Phase II Study of Coexpression Extrapolation (COXEN) with Neoadjuvant Chemotherapy for Bladder Cancer (SWOG S1314; NCT02177695).Clin Cancer Res. 2021 May 1;27(9):2435-2441. doi: 10.1158/1078-0432.CCR-20-2409. Epub 2021 Feb 10. Clin Cancer Res. 2021. PMID: 33568346 Free PMC article. Clinical Trial.
-
Using Cell Lines To Guide Neoadjuvant Therapy in Bladder Cancer: COXEN and SWOG S1314.Eur Urol Focus. 2022 May;8(3):648-650. doi: 10.1016/j.euf.2022.03.013. Epub 2022 Mar 23. Eur Urol Focus. 2022. PMID: 35339415 Free PMC article.
-
Predicting response to neoadjuvant chemotherapy in muscle-invasive bladder cancer via interpretable multimodal deep learning.NPJ Digit Med. 2025 Mar 22;8(1):174. doi: 10.1038/s41746-025-01560-y. NPJ Digit Med. 2025. PMID: 40121304 Free PMC article.
-
Neoadjuvant chemotherapy in patients with invasive bladder cancer.Urol Clin North Am. 2005 May;32(2):231-7. doi: 10.1016/j.ucl.2005.03.001. Urol Clin North Am. 2005. PMID: 15862620 Review.
References
Publication types
LinkOut - more resources
Full Text Sources