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Editorial
. 2024 Apr 9:13:e97432.
doi: 10.7554/eLife.97432.

How to pause fertility

Aleisha M Moore  1
Affiliations
Editorial

How to pause fertility

Aleisha M Moore. Elife. .

Abstract

Prolactin suppresses the ovarian cycles of lactating mice by directly repressing the activity of a cell population known as kisspeptin neurons.

Keywords: GnRH pulse generator; fertility; kisspeptin neurons; lactational amenorrhea; mouse; neuroscience.

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Conflict of interest statement

AM No competing interests declared

Figures

Figure 1.
Figure 1.. Activity of arcuate kisspeptin neurons over different reproductive states.
(A) Mice were genetically manipulated so that kisspeptin neurons in their arcuate nucleus produced a fluorescent calcium indicator that emits light (blue) when the cell is active. This signal can be detected via an optic fiber implanted in the animal (grey rod in inset) and relayed to a photometry system (black cable). (B) Episodic activity of kisspeptin neurons can be detected in virgin mice, but not during lactation. In contrast, such activity is present in lactating mice in which the prolactin receptor has been genetically deleted from kisspeptin (kiss1) cells.
See this image and copyright information in PMC

Comment on

  • doi: 10.7554/eLife.94570

References

    1. Brown RSE, Khant Aung Z, Phillipps HR, Barad Z, Lein HJ, Boehm U, Szawka RE, Grattan DR. Acute suppression of LH secretion by prolactin in female mice is mediated by kisspeptin neurons in the arcuate nucleus. Endocrinology. 2019;160:1323–1332. doi: 10.1210/en.2019-00038. - DOI - PubMed
    1. Clarke H, Dhillo WS, Jayasena CN. Comprehensive review on kisspeptin and its role in reproductive disorders. Endocrinology and Metabolism. 2015;30:124–141. doi: 10.3803/EnM.2015.30.2.124. - DOI - PMC - PubMed
    1. Clarkson J, Han SY, Piet R, McLennan T, Kane GM, Ng J, Porteous RW, Kim JS, Colledge WH, Iremonger KJ, Herbison AE. Definition of the hypothalamic GnRH pulse generator in mice. PNAS. 2017;114:E10216–E10223. doi: 10.1073/pnas.1713897114. - DOI - PMC - PubMed
    1. Georgescu T, Swart JM, Grattan DR, Brown RSE. The prolactin family of hormones as regulators of maternal mood and behavior. Frontiers in Global Women’s Health. 2021;2:767467. doi: 10.3389/fgwh.2021.767467. - DOI - PMC - PubMed
    1. Hackwell ECR, Ladyman SR, Clarkson J, McQuillan HJ, Boehm U, Herbison AE, Brown RSE, Grattan DR. Prolactin mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice. eLife. 2024;13:RP94570. doi: 10.7554/eLife.94570. - DOI

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