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. 1985 May;37(3):482-98.

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

G M Lathrop, J M Lalouel, C Julier, J Ott

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination

G M Lathrop et al. Am J Hum Genet. 1985 May.

Abstract

Multilocus linkage analysis is investigated from the viewpoint of the efficiency of recombination estimates under different strategies for detecting linkage and determining gene order within a linkage group. We consider the appropriateness of assuming no interference with data available in human genetic studies. Examples are given to show the significance of multilocus analysis in humans. A computer program package, LINKAGE, for multilocus linkage analysis is described.

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References

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