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. 2024 Oct;50(5):2281-2287.
doi: 10.1007/s00068-024-02488-w. Epub 2024 Apr 9.

How does damage control strategy influence organ's suitability for donation after major trauma? A multi-institutional study

Michele Altomare  1   2 , Shir Sara Bekhor  3 , Marco Sacchi  4 , Federico Ambrogi  5 , Gabriele Infante  6   7 , Arturo Chieregato  8 , Federico Pozzi  8 , Tullia Maria De Feo  9 , Lorenza Nava  10 , Elisabetta Masturzo  10 , Luca Del Prete  11 , Carolina Perali  11 , Elena Manzo  12 , Paolo Bertoli  13 , Francesco Virdis  3 , Andrea Spota  3 , Stefano Piero Bernardo Cioffi  14   3 , Laura Benuzzi  15 , Giuliano Santolamazza  15 , Mauro Podda  16 , Andrea Mingoli  14 , Osvaldo Chiara  3   17 , Stefania Cimbanassi  3   17
Affiliations

How does damage control strategy influence organ's suitability for donation after major trauma? A multi-institutional study

Michele Altomare et al. Eur J Trauma Emerg Surg. 2024 Oct.

Erratum in

No abstract available

Keywords: Damage control; Damage control strategy; Damage control surgery; Major trauma; Organ donation; Trauma Donors.

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Conflict of interest statement

Declarations. Institutional Review Board statement: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of ASST GOM Niguarda. All enrolled patients were extracted from our prospectively collected database, including Trauma and Acute Care Surgery Patients, registered within our Ethics Committee Milano Area 3 with the following code: 534–102018 (Dec. 2018). Consent to participate: Informed consent was obtained from all subjects involved in the study. In this registry-based study, patients were informed that their completely anonymized data could be further used for scientific studies. All patients or parents enrolled signed an informed consent to allow data collection for scientific purposes. Conflict of interest: The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
A According to the elbow method, the optimal number of clusters is two. B According to the silhouette method, the optimal number of clusters is two. C According to the gap statistics method, the optimal number of clusters is four
Fig. 2
Fig. 2
Clustering heatmap of 117 trauma donors has identified two main clusters. Pre_HR, pre-hospital heart rate; Pre_SI, pre-hospital shock index; ED_pH, pH level measured in the emergency department; ED_BE, base excess levels measured in the emergency department; Pre_SBP, pre-hospital systolic blood pressure; ED_SBP, emergency department systolic blood pressure; Pre_GCS, pre-hospital Glasgow Coma Scale; ED_GCS, emergency department Glasgow Coma Scale; BMI, body mass index; ISS, injury severity score; ED_CA, cardiac arrest at admission to emergency department; ED_Lac, lactate levels measured in emergency department; ED_HR, emergency department heart rate; ED_SI, emergency department shock index; Pre_CA, pre-hospital cardiac arrest; delta_SI, difference between pre-hospital and emergency department shock index. Organ: total number of donated organs, from 1 to 8 (including heart, lungs, liver, kidneys, and pancreas). Hospital: 1, Niguarda; 2, Papa Giovanni; 3, Policlinico
Fig. 3
Fig. 3
Logistic regression of heart donation (dependent variable) as a function of age and cluster (independent variables) demonstrating that the effect of age is different in each cluster
See this image and copyright information in PMC

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