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Case Reports
. 1985 Mar;4(3):683-6.
doi: 10.1002/j.1460-2075.1985.tb03683.x.

C-abl and bcr are rearranged in a Ph1-negative CML patient

C R Bartram, E Kleihauer, A de Klein, G Grosveld, J R Teyssier, N Heisterkamp, J Groffen
Case Reports

C-abl and bcr are rearranged in a Ph1-negative CML patient

C R Bartram et al. EMBO J. 1985 Mar.

Abstract

Chromosomal analysis of a patient with chronic myelocytic leukemia (CML) revealed a translocation (9;12) (q34;q21) without a detectable Philadelphia chromosome (Ph1). Using molecular approaches we demonstrate (i) a rearrangement within the CML breakpoint cluster region (bcr) on chromosome 22, and (ii) a joint translocation of bcr and c-abl oncogene sequences to the derivative chromosome 12. These observations support the view that sequences residing on both chromosome 9 (c-abl) and 22 (bcr) are involved in the generation of CML and suggest that a subset of Ph1-negative patients may in fact belong to the clinical entity of Ph1-positive CML.

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