Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Feb;16(Suppl 1):S570-S573.
doi: 10.4103/jpbs.jpbs_868_23. Epub 2023 Dec 20.

Clinical Efficacy of Topical Kenacort and Aloe Vera Gel in Minor Aphthous Stomatitis: A Comparative Study

Mehak Tariq  1 , Vishwanath V Jalli  2 , J Dhurubatha  3 , Reeturaj Medhi  4 , Kanchan Malawat  5 , Inderjit M Gowdar  6 , Sugandha Arya  7
Affiliations

Clinical Efficacy of Topical Kenacort and Aloe Vera Gel in Minor Aphthous Stomatitis: A Comparative Study

Mehak Tariq et al. J Pharm Bioallied Sci. 2024 Feb.

Abstract

Aim: The aim of the study is to compare the clinical efficacy of both the topical agents-aloe vera gel and Kenacort oral paste (0.1% triamcinolone acetonide) in patients with minor aphthous stomatitis.

Materials and methods: 60 patients were recruited for the study and were randomly divided into two groups-Group A (aloe vera gel group) and Group B (Kenacort oral paste group). The baseline parameters were taken and recorded on the day of the first visit which included ulcer size, pain, and burning sensation. Evaluation of reduction in ulcer size, pain, and burning sensation were made on day 3 and day 7.

Results: The results of the present study revealed that both the study groups showed no significant difference in the size of ulcer at day 1, day 3, and day 7 when compared using independent t-test as P > 0.05 at all study intervals. Therefore, both the agents were found to be equally effective against reducing the size of ulcer, pain, and burning sensation.

Conclusion: The present study findings demonstrate that topical application of the aloe vera gel was able to decrease the ulcer size, intensity of pain, and burning sensation, thereby accelerating the healing without any side effects. Thus, topical aloe vera could be safe and a better alternative to topical steroid for RAS.

Keywords: Aloe vera; minor aphthous stomatitis; triamcinolone acetonide.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Comparison of ulcer sizes and VAS score for pain and burning sensation among the study groups at different time intervals
See this image and copyright information in PMC

References

    1. Edgar NR, Saleh D, Miller RA. Recurrent aphthous stomatitis: A review. J Clin Aesthet Dermatol. 2017;10:26–36. - PMC - PubMed
    1. Giroh VR, Hebbale M, Mhapuskar A, Hiremutt D, Agarwal P. Efficacy of aloe vera and triamcinolone acetonide 0.1% in recurrent aphthous stomatitis: A preliminary comparative study. J Indian Acad Oral Med Radiol. 2019;31:45–50.
    1. Nazeer S, Patil P, Mohammed I, Ramesh Goud SV. Clinical efficacy of aloe vera and triamcinolone acetonide in the management of minor recurrent aphthous stomatitis: A randomised double-blind clinical study. IJDSIR. 2019;2:79–89.
    1. Nassaji M, Ghorbani R. Risk factors associated with minor recurrent aphthous ulcers in adult population of Semnan city in Iran: An epidemiological study. Asian J Oral Health Allied Sci. 2012;2:3–7.
    1. Patil S, Reddy SN, Maheshwari S, Khandelwal S, Shruthi D, Doni B. Prevalence of recurrent aphthous ulceration in the Indian population. J Clin Exp Dent. 2014;6:e36–40. - PMC - PubMed