Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Feb;16(Suppl 1):S41-S45.
doi: 10.4103/jpbs.jpbs_838_23. Epub 2024 Feb 29.

Next-Generation Sequencing (NGS): Platforms and Applications

Affiliations
Review

Next-Generation Sequencing (NGS): Platforms and Applications

Jyoti S Mandlik et al. J Pharm Bioallied Sci. 2024 Feb.

Abstract

The demand for accurate, faster, and inexpensive sequencing of deoxyribonucleic acid (DNA) is increasing and is driving the emergence of next-generation sequencing (NGS) technologies. NGS can provide useful insights to help researchers and clinicians to develop the right treatment options. NGS has wide applications in novel fields in biology and medicine. These technologies are of great aid to decode mysteries of life, to improve the quality of crops to detect the pathogens, and also useful in improving life qualities. Thousands to millions of molecules can be sequenced simultaneously in parallel using various NGS methods. NGS can identify and characterize the microbial species more comprehensively than culture-based methods. Recently, the NGS approach has been used for oral microbial analysis.

Keywords: DNA; NGS; Oral microbial analysis.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Similar articles

Cited by

References

    1. Watson JD, Crick FH. Molecular structure of nucleic acids: A structure for deoxyribose nucleic acid. Nature. 1953;171:737–8. - PubMed
    1. Kchouk M, Gibrat JF, Elloumi M. Generations of sequencing technologies: From first to next generation. Biol Med (Aligarh) 2017;9:395.
    1. Raza K, Ahmed S. Recent advancements in next generation Sequencing techniques and its computational analysis. IntJ Bioinform Res and Appl. 2019;15:191–220.
    1. Rizzo JM, Buck MJ. Key principles and clinical applications of “Next-generation”DNA sequencing. Cancer Prev Res (Phila) 2012;5:887–900. - PubMed
    1. Gullapalli RR, Desai KV, Santos LS, Kant JA, Becich MJ. Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics. J Pathol Inform. 2012;3:40. - PMC - PubMed