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Review
. 2024 Mar 10;16(3):e55902.
doi: 10.7759/cureus.55902. eCollection 2024 Mar.

Gastric Cancer: A Comprehensive Literature Review

Reda H Mithany  1 , M Hasaan Shahid  2 , Mina Manasseh  3 , Muhammad Talha Saeed  4 , Samana Aslam  5 , Mohamed S Mohamed  6 , Nesma Daniel  7
Affiliations
Review

Gastric Cancer: A Comprehensive Literature Review

Reda H Mithany et al. Cureus. .

Abstract

Gastric cancer stands as a significant global health concern, particularly prevalent in Eastern Asia, with high mortality rates urging urgent attention and research efforts. This article comprehensively explores the epidemiology, anatomy, risk factors, pathophysiology, clinical presentation, diagnosis, staging, treatment modalities, prevention strategies, and survival rates associated with gastric cancer. Notably, Helicobacter pylori infection, dietary choices, and intricate stomach anatomy play pivotal roles in disease development. Early detection, utilizing staging, grading, and genetic testing for personalized treatment approaches is emphasized. Treatment modalities encompass surgery, chemotherapy, radiation therapy, targeted therapy, and immunotherapy. Prevention strategies involve lifestyle changes, screening, and genetic counseling. Survival rates vary by stage, highlighting the need for individualized care. In conclusion, a collaborative global effort is essential to address the impact of gastric cancer and improve outcomes.

Keywords: 5 year survival; gastric cancer; gastric neoplasia; gastric surgery; gastrointestinal bleeding.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Anatomy of the stomach.
Image Credit: Reda Harby (author)
Figure 2
Figure 2. Gastric lymphatic drainage.
Image Credit: Reda Harby (author)
See this image and copyright information in PMC

References

    1. Burden of gastric cancer. Thrift AP, El-Serag HB. Clin Gastroenterol Hepatol. 2020;18:534–542. - PMC - PubMed
    1. Gastric and esophageal cancer in China 2000 to 2030: recent trends and short-term predictions of the future burden. Zhou J, Zheng R, Zhang S, et al. Cancer Med. 2022;11:1902–1912. - PMC - PubMed
    1. Chaudhry SR, Liman MN, Peterson DC. StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; [ Nov; 2023 ]. 2022. Anatomy, abdomen and pelvis: stomach. - PubMed
    1. Rao JN, Wang JY. Regulation of Gastrointestinal Mucosal Growth. San Rafael (CA): Morgan & Claypool Life Sciences; [ Nov; 2023 ]. 2010. Intestinal architecture and development. - PubMed
    1. Ahluwalia N, Nassereddin A, Futterman B. StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2024. Anatomy, abdomen and pelvis: celiac trunk. - PubMed

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