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Review
. 2024 Mar 26:15:1379742.
doi: 10.3389/fimmu.2024.1379742. eCollection 2024.

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Chun-Lian Huang #  1 , Xin-Yu Fu #  2 , Yi Feng  2 , Xiao-Kang Li  3   4 , Yi Sun  5 , Xin-Li Mao  3   6   7 , Shao-Wei Li  3   6   7
Affiliations
Review

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Chun-Lian Huang et al. Front Immunol. .

Abstract

Background: Kidney transplantation is considered the most effective treatment for end-stage renal failure. Recent studies have shown that the significance of the immune microenvironment after kidney transplantation in determining prognosis of patients. Therefore, this study aimed to conduct a bibliometric analysis to provide an overview of the knowledge structure and research trends regarding the immune microenvironment and survival in kidney transplantation.

Methods: Our search included relevant publications from 2013 to 2023 retrieved from the Web of Science core repository and finally included 865 articles. To perform the bibliometric analysis, we utilized tools such as VOSviewer, CiteSpace, and the R package "bibliometrix". The analysis focused on various aspects, including country, author, year, topic, reference, and keyword clustering.

Results: Based on the inclusion criteria, a total of 865 articles were found, with a trend of steady increase. China and the United States were the countries with the most publications. Nanjing Medical University was the most productive institution. High-frequency keywords were clustered into 6 areas, including kidney transplantation, transforming growth factor β, macrophage, antibody-mediated rejection, necrosis factor alpha, and dysfunction. Antibody mediated rejection (2019-2023) was the main area of research in recent years.

Conclusion: This groundbreaking bibliometric study comprehensively summarizes the research trends and advances related to the immune microenvironment and survival after kidney transplantation. It identifies recent frontiers of research and highlights promising directions for future studies, potentially offering fresh perspectives to scholars in the field.

Keywords: CiteSpace; VOSview; bibliometrics; immune microenvironment; kidney transplantation; survival.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.

Figures

Figure 1
Figure 1
Screening flowchart for inclusion of studies.
Figure 2
Figure 2
Annual yield of research on the immune microenvironment related to survival after kidney transplantation.
Figure 3
Figure 3
Map of collaboration between different countries (A). Trends in publication distribution in the top five countries (B).
Figure 4
Figure 4
Top 10 countries in terms of articles published in the field between 2013-2023.
Figure 5
Figure 5
Collaborative networks between authors and between countries (A). Countries associated with authorsVisualization map between authors (B).
Figure 6
Figure 6
Institution (A), country (B) and the 10 most cited references to which the publication relates. The red bar indicates the year with the most citations (C).
Figure 7
Figure 7
Clustering of keywords in studies related to the immune microenvironment and survival after kidney transplantation (A–C). Top 25 most cited keywords (D).
See this image and copyright information in PMC

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