The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review

Christopher P Millward^{1

2}, Abdurrahman I Islim^{1

2}, Terri S Armstrong³, Heather Barrington⁴, Sabrina Bell⁵, Andrew R Brodbelt^{1

2}, Helen Bulbeck⁶, Linda Dirven^{7

8}, Paul L Grundy⁹, Mohsen Javadpour¹⁰, Sumirat M Keshwara^{1

2}, Shelli D Koszdin¹¹, Anthony G Marson^{1

12}, Michael W McDermott¹³, Torstein R Meling¹⁴, Kathy Oliver¹⁵, Puneet Plaha¹⁶, Matthias Preusser¹⁷, Thomas Santarius¹⁸, Nisaharan Srikandarajah^{1

2}, Martin J B Taphoorn^{7

8}, Carole Turner¹⁸, Colin Watts¹⁹, Michael Weller²⁰, Paula R Williamson⁴, Gelareh Zadeh²¹, Amir H Zamanipoor Najafabadi²², Michael D Jenkinson^{1

2}; EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada

Collaborators, Affiliations

Collaborators

EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada:
Kenneth Aldape, Abdurrahman I Islim, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Felix Behling, Priscilla K Brastianos, Chaya Brodie, Nicholas Butowski, Carlos Carlotti, Ana Castro, Aaron Cohen-Gadol, Marta Couce, Michael D Cusimano, Francesco DiMeco, Katharine Drummond, Ian F Dunn, Craig Erker, Michelle Felicella, Daniel M Fountain, Evanthia Galanis, Norbert Galldiks, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C Oliver Hanemann, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Raymond Y Huang, David James, Michael D Jenkinson, Christine Jungk, Gerhard Jungwirth, Timothy J Kaufmann, Boris Krischek, Sylvia Kurz, Daniel Lachance, Christian Lafougère, Katrin Lamszus, Ian Lee, Jeff C Liu, Serge Makarenko, Tathiana Malta, Yasin Mamatjan, Alireza Mansouri, Christian Mawrin, Michael McDermott, Christopher P Millward, Jennifer Moliterno-Gunel, Andrew Morokoff, David Munoz, Farshad Nassiri, Houtan Noushmehr, Ho-Keung Ng, Arie Perry, Farhad Pirouzmand, Laila M Poisson, Bianca Pollo, Aditya Ragunathan, David Raleigh, Mirjam Renovanz, Franz Ricklefs, Felix Sahm, Andrea Saladino, Antonio Santacroce, Thomas Santarius, Jens Schittenhelm, Christian Schichor, David Schultz, Nils O Schmidt, Warren Selman, Helen Shih, Andrew Sloan, Julian Spears, Matija Snuderl, James Snyder, Suganth Suppiah, Erik Sulman, Ghazaleh Tabatabai, Marcos Tatagiba, Marco Timmer, Daniela Tirapelli, Joerg C Tonn, Derek Tsang, Michael A Vogelbaum, Andreas von Deimling, Tobias Walbert, Simon Walling, Justin Wang, Patrick Y Wen, Manfred Westphal, Adriana M Workewych, Stephen Yip, Gabriel Zada, Gelareh Zadeh, Viktor Zherebitskiy

Affiliations

¹ Institute of Systems, Molecular, & Integrative Biology, University of Liverpool, Liverpool, UK.
² Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
³ Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
⁴ Institute of Population Health, University of Liverpool, Liverpool, UK.
⁵ The Brain Tumour Charity, Hampshire, UK.
⁶ Brainstrust - The Brain Cancer People, Isle of Wight, UK.
⁷ Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
⁸ Department of Neurology, Haaglanden Medical Center, The Hague, The Netherlands.
⁹ Department of Neurosurgery, University Hospital Southampton, Southampton, UK.
¹⁰ National Centre for Neurosurgery, Beaumont Hospital, Dublin, Ireland.
¹¹ Veterans Affairs Healthcare System, Palo Alto, California, USA.
¹² Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.
¹³ Division of Neuroscience, Florida International University, Miami, Florida, USA.
¹⁴ Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.
¹⁵ International Brain Tumour Alliance, Tadworth, UK.
¹⁶ Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
¹⁷ Division of Oncology, Department of Medicine, Medical University of Vienna, Vienna, Austria.
¹⁸ Department of Neurosurgery, Addenbrooke's Hospital & University of Cambridge, Cambridge, UK.
¹⁹ Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
²⁰ Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
²¹ Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
²² Department of Ophthalmology, Leiden University Medical Centre, Haaglanden Medical Center, Haga Teaching Hospitals, Leiden and The Hague, The Netherlands.

PMID: 38596715
PMCID: PMC11003528
DOI: 10.1093/noajnl/vdae042

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review

Christopher P Millward et al. Neurooncol Adv. 2024.

. 2024 Mar 19;6(1):vdae042.

doi: 10.1093/noajnl/vdae042. eCollection 2024 Jan-Dec.

Authors

Collaborators

EORTC BTG, ICOM, EANO, SNO, RANO-PRO, BNOS, SBNS, BIMS, TBTC, International Brain Tumour Alliance, Brainstrust, and Brain Tumour Foundation of Canada:
Kenneth Aldape, Abdurrahman I Islim, Karolyn Au, Jill Barnhartz-Sloan, Wenya Linda Bi, Felix Behling, Priscilla K Brastianos, Chaya Brodie, Nicholas Butowski, Carlos Carlotti, Ana Castro, Aaron Cohen-Gadol, Marta Couce, Michael D Cusimano, Francesco DiMeco, Katharine Drummond, Ian F Dunn, Craig Erker, Michelle Felicella, Daniel M Fountain, Evanthia Galanis, Norbert Galldiks, Caterina Giannini, Roland Goldbrunner, Brent Griffith, Rintaro Hashizume, C Oliver Hanemann, Christel Herold-Mende, Luke Hnenny, Craig Horbinski, Raymond Y Huang, David James, Michael D Jenkinson, Christine Jungk, Gerhard Jungwirth, Timothy J Kaufmann, Boris Krischek, Sylvia Kurz, Daniel Lachance, Christian Lafougère, Katrin Lamszus, Ian Lee, Jeff C Liu, Serge Makarenko, Tathiana Malta, Yasin Mamatjan, Alireza Mansouri, Christian Mawrin, Michael McDermott, Christopher P Millward, Jennifer Moliterno-Gunel, Andrew Morokoff, David Munoz, Farshad Nassiri, Houtan Noushmehr, Ho-Keung Ng, Arie Perry, Farhad Pirouzmand, Laila M Poisson, Bianca Pollo, Aditya Ragunathan, David Raleigh, Mirjam Renovanz, Franz Ricklefs, Felix Sahm, Andrea Saladino, Antonio Santacroce, Thomas Santarius, Jens Schittenhelm, Christian Schichor, David Schultz, Nils O Schmidt, Warren Selman, Helen Shih, Andrew Sloan, Julian Spears, Matija Snuderl, James Snyder, Suganth Suppiah, Erik Sulman, Ghazaleh Tabatabai, Marcos Tatagiba, Marco Timmer, Daniela Tirapelli, Joerg C Tonn, Derek Tsang, Michael A Vogelbaum, Andreas von Deimling, Tobias Walbert, Simon Walling, Justin Wang, Patrick Y Wen, Manfred Westphal, Adriana M Workewych, Stephen Yip, Gabriel Zada, Gelareh Zadeh, Viktor Zherebitskiy

Affiliations

¹ Institute of Systems, Molecular, & Integrative Biology, University of Liverpool, Liverpool, UK.
² Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.
³ Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
⁴ Institute of Population Health, University of Liverpool, Liverpool, UK.
⁵ The Brain Tumour Charity, Hampshire, UK.
⁶ Brainstrust - The Brain Cancer People, Isle of Wight, UK.
⁷ Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
⁸ Department of Neurology, Haaglanden Medical Center, The Hague, The Netherlands.
⁹ Department of Neurosurgery, University Hospital Southampton, Southampton, UK.
¹⁰ National Centre for Neurosurgery, Beaumont Hospital, Dublin, Ireland.
¹¹ Veterans Affairs Healthcare System, Palo Alto, California, USA.
¹² Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.
¹³ Division of Neuroscience, Florida International University, Miami, Florida, USA.
¹⁴ Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.
¹⁵ International Brain Tumour Alliance, Tadworth, UK.
¹⁶ Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
¹⁷ Division of Oncology, Department of Medicine, Medical University of Vienna, Vienna, Austria.
¹⁸ Department of Neurosurgery, Addenbrooke's Hospital & University of Cambridge, Cambridge, UK.
¹⁹ Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
²⁰ Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
²¹ Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
²² Department of Ophthalmology, Leiden University Medical Centre, Haaglanden Medical Center, Haga Teaching Hospitals, Leiden and The Hague, The Netherlands.

PMID: 38596715
PMCID: PMC11003528
DOI: 10.1093/noajnl/vdae042

Abstract

Background: The clinical management of patients with incidental intracranial meningioma varies markedly and is often based on clinician choice and observational data. Heterogeneous outcome measurement has likely hampered knowledge progress by preventing comparative analysis of similar cohorts of patients. This systematic review aimed to summarize the outcomes measured and reported in observational studies.

Methods: A systematic literature search was performed to identify published full texts describing active monitoring of adult cohorts with incidental and untreated intracranial meningioma (PubMed, EMBASE, MEDLINE, and CINAHL via EBSCO, completed January 24, 2022). Reported outcomes were extracted verbatim, along with an associated definition and method of measurement if provided. Verbatim outcomes were de-duplicated and the resulting unique outcomes were grouped under standardized outcome terms. These were classified using the taxonomy proposed by the "Core Outcome Measures in Effectiveness Trials" (COMET) initiative.

Results: Thirty-three published articles and 1 ongoing study were included describing 32 unique studies: study designs were retrospective n = 27 and prospective n = 5. In total, 268 verbatim outcomes were reported, of which 77 were defined. Following de-duplication, 178 unique verbatim outcomes remained and were grouped into 53 standardized outcome terms. These were classified using the COMET taxonomy into 9 outcome domains and 3 core areas.

Conclusions: Outcome measurement across observational studies of incidental and untreated intracranial meningioma is heterogeneous. The standardized outcome terms identified will be prioritized through an eDelphi survey and consensus meeting of key stakeholders (including patients), in order to develop a Core Outcome Set for use in future observational studies.

Keywords: COMET; Core Outcome Set; incidental; meningioma; outcomes.

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Conflict of interest statement

M.D.J. received a grant from the National Institute for Health Research Health Technology Assessment program for the Radiation versus Observation for Atypical Meningioma (ROAM) trial (NIHR ID: 12/173/14). M.D.J. and S.J.M. received a grant from the National Institute for Health Research Health Technology Assessment program for Surgeons Trial Of Prophylaxis for Epilepsy in seizure naïve patients with Meningioma (STOP’EM) (NIHR ID: NIHR129748). T.S. founded and leads the Anaplastic Meningioma International Consortium (AMiCo). T.S. and M.D.J. cofounded the British-Irish Meningioma Society (BIMS). A.G.M. is a National Institute for Health Research (NIHR) Senior Investigator and is also part-funded by NIHR ARC North West Coast. The views expressed in this article are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. M.P. has received honoraria for lectures, consultation or advisory board participation from the following for-profit companies: Bayer, Bristol-Myers Squibb, Novartis, Gerson Lehrman Group (GLG), CMC Contrast, GlaxoSmithKline, Mundipharma, Roche, BMJ Journals, MedMedia, Astra Zeneca, AbbVie, Lilly, Medahead, Daiichi Sankyo, Sanofi, Merck Sharp & Dome, Tocagen, Adastra, Servier. M.W. has received research grants from Quercis and Versameb, and honoraria for lectures or advisory board participation or consulting from Bayer, Curevac, Medac, Novartis, Novocure, Orbus, Philogen, Roche and Sandoz.

Figures

**Figure 1.**
PRISMA flow diagram depicting the identification, screening, eligibility, and inclusion of unique published studies and ongoing studies.

**Figure 2.**
Reporting frequency of standardized outcome terms, along with the proportion of those defined vs undefined for each.

See this image and copyright information in PMC

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The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review

Collaborators

Affiliations

The outcomes measured and reported in observational studies of incidental and untreated intracranial meningioma: A systematic review

Authors

Collaborators

Affiliations

Abstract

Conflict of interest statement

Figures

References

LinkOut - more resources

Full Text Sources