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. 2024 Dec 31;17(1):2325728.
doi: 10.1080/16549716.2024.2325728. Epub 2024 Apr 10.

Health-related quality of life among adult patients with cancer in Uganda - a cross-sectional study

Allen Naamala  1   2 , Lars E Eriksson  3   4   5 , Jackson Orem  2 , Gorrette K Nalwadda  1 , Zarina Nahar Kabir  3 , Lena Wettergren  6   7
Affiliations

Health-related quality of life among adult patients with cancer in Uganda - a cross-sectional study

Allen Naamala et al. Glob Health Action. .

Abstract

Objectives: The study aimed to investigate the prevalence and factors associated with poor health-related quality of life in adults with cancer in Uganda.

Methods: This cross-sectional study surveyed 385 adult patients (95% response rate) with various cancers at a specialised oncology facility in Uganda. Health-related quality of life was measured using the EORTC QLQ-C30 in the Luganda and English languages. Predetermined validated clinical thresholds were applied to the instrument in order to identify patients with poor health-related quality of life, that is, functional impairments or symptoms warranting concern. Multivariable logistic regression was used to identify factors associated with poor health-related quality of life in six subscales: Physical Function, Role Function, Emotional Function, Social Function, Pain and Fatigue.

Results: The mean age of the patients was 48 years. The majority self-reported poor functioning ranging between 61% (Emotional Function) to 79% (Physical Function) and symptoms (Fatigue 63%, Pain 80%) at clinically concerning levels. These patients were more likely to be older, without formal education and not currently working. Being an inpatient at the facility and being diagnosed with cervical cancer or leukaemia was a predictor of poor health-related quality of life.

Conclusion: Improvement of cancer care in East Africa requires a comprehensive and integrated approach that addresses various challenges specific to the region. Such strategies include investment in healthcare infrastructure, for example, clinical guidelines to improve pain management, and patient education and support services.

Keywords: Cancer care facilities; Uganda; health status; health-related quality of life; neoplasms.

Plain language summary

Main findings: The majority of adult patients attending specialized cancer care in Uganda report impaired physical and emotional functioning, and pain, at levels that merit clinical concern.Added knowledge: The large proportion of in- and outpatients with poor self-reported health-related quality of life indicates supportive care needs, exceeding corresponding figures from high-income settings.Global health impact for policy and action: Improvement of cancer care in East Africa requires a comprehensive approach that should include investment in healthcare infrastructure, e.g. clinical guidelines to improve pain management, and patient education and support services.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

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