Progress of research on oral mucosal adhesive agents

Abstract

Oral mucosal administration is extensively used to treat systemic diseases and oral mucosal diseases owing to unique oral mucosal structure and convenient administration. However, the special microenvironment of the oral cavity being open, moving, and humid causes oral mucosal drug delivery to face great challenges. To address this dilemma, local adhesive agents have been widely studied for sustained drug delivery and improved bioavailability, showing broad prospects. Recently, the author has performed studies on oral mucosal adhesive agents. In this paper, the progress of research on oral mucosal adhesive materials is reviewed.

Keywords: adhesion; local administration; oral mucosa.

图 1. 黏附材料与黏蛋白黏附作用机制的5种理论解释

Fig 1 Five theories for explaining the adhesive mechanism between materials and mucins A：吸附理论；B：润湿理论；C：电荷理论；D：扩散理论；E：断裂理论。

图 2. 口腔黏膜黏附给药剂型示意图

Fig 2 Scheme of oral adhesive formulations

图 3. 测试黏附力装置示意图

Fig 3 Schematic diagram of the devices for testing adhesion A：自制装置模式图；B：质构分析仪模式图。