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. 2024 Apr 10:83:132-139.
doi: 10.2340/aos.v83.40337.

Assessment of jaw bone mineral density, resorption rates, and oral health in patients with severe hemophilia: a case-control study

Gülin Acar  1 , Alper Aktaş  2
Affiliations

Assessment of jaw bone mineral density, resorption rates, and oral health in patients with severe hemophilia: a case-control study

Gülin Acar et al. Acta Odontol Scand. .

Abstract

Objective: Knowledge about oral hygiene, gingival bleeding, mineral density, and resorption of jaw bones in patients with hemophilia is limited. We evaluated the periodontal and bone status in such patients. Material and methods: Forty-eight patients with severe type A/B hemophilia and 49 age- and sex-matched controls were included. Assessments included simplified oral hygiene index (OHI-S), calculus index, debris index, gingival index (GI), gingival bleeding time index (GBTI), and decayed, missing, and filled teeth index (DMFTI). Bone resorption was evaluated using panoramic mandibular index (PMI), mental index (MI), and alveolar crest ratio (ACR). Mineral density in the condyle, angulus, and premolar areas was assessed using fractal analysis, with fractal dimensions denoted as condyle fractal dimension (CFD) for the condyle, angulus fractal dimension (AFD) for angulus, and premolar fractal dimension (PFD) for premolar region.

Results: The mean scores were DMFTI = 11.77, OHI-S = 2.44, PMI = 0.268, MI = 5.822, GI = 3.02, GBTI = 2.64, ACR = 2.06, CFD = 1.31, AFD = 1.31, and PFD = 1.17 in the hemophilia group and DMFTI = 11.449, PMI = 0.494, MI = 7.43, GI = 0.67, GBTI = 0.98, OHI-S = 1.45, ACR = 2.87, CFD = 1.35, AFD = 1.35, and PDF = 1.23 in the control group. Differences were significant for all parameters (p < 0.005) except for the DMFTI index. Conclusions: Because of poor oral hygiene, high bone resorption, and low bone mineral density in these patients, clinicians should consider potential bone changes when planning to treat these patients.

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Conflict of interest statement

The authors report that there are no conflict of interest to declare.

Figures

Figure 1
Figure 1
(Left) Line perpendicular to the line parallel to the mandibular cortex, passing through the center of the mental foramen, which was used for evaluation (Right). Calculations of mathematical ratios. ACR: alveolar crest ratio, PMI: panoramic mandibular index, MI: mental index.
Figure 2
Figure 2
Regions of interest on the condyle, angulus, and premolar regions for fractal analysis.
See this image and copyright information in PMC

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